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Table 1 Associations between SNPs in TLRs and gB-Specific Antibody Responses After 3 doses of CMV vaccine

From: Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine

Gene SNP Location Minor Allele Counts* β Standard Error P value Median ELISA**
TLR7 rs179009 intron C 4/47/91 0.386 0.116 0.001 21102/13194/9769
TLR7 rs179008 coding T 4/34/104 0.304 0.128 0.019 21102/12907/10340
TLR7 rs179018 intron G 4/36/102 0.318 0.130 0.016 16610/12907/10691
TLR7 rs179013 intron T 3/34/105 0.315 0.136 0.022 22940/13501/10530
IKBKE rs1953090 intron C 15/62/64 -0.275 0.097 0.005 10904/9676/14993
TLR3 rs3775292 intron G 5/40/96 0.296 0.117 0.012 10904/13685/9662
IRAK4 rs1838341 intron G 0/16/126 -0.458 0.204 0.027 NA/6394/11378
TLR9 rs5743849 intron T 0/16/126 -0.469 0.211 0.028 NA/6635/11424
  1. *Counts are presented as the number of women homozygous for the minor allele/heterozygous/homozygous for the major allele
  2. **Median ELISA- the median gB antibody titer measured in each of the three groups