Skip to main content

Table 1 Inflammatory mediators of interest

From: Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial

Mediator

Role in Pyrexia or Inflammation

Reference

IL-1β

Potent endogenous pyrogen

[30]

IL-1RA

Endogenous anti-pyretic cytokine

[31]

Il-4

Key mediator of humoral and adaptive immunity

[32]

IL-6

Potent pro-inflammatory cytokine and pyrogen

[30]

IL-8

Neutrophil chemotactic factor

[33]

IL-10

Endogenous anti-pyretic cytokine

[34]

IL-17

Potent pro-inflammatory mediator

[35]

IL-18

Amplifies the innate immune response

[36]

IFN-γ

Endogenous pyrogen

[30]

TNF-α

Endogenous pyrogen and ubiquitous inflammatory mediator

[37]

RANTES

Chemotactic factor for T-cells, dendritic cells, and NK cells

[38]

MIP-1α

Leukocyte chemotactic factor

[39]

GRO-α

Neutrophil chemotactic factor

[40]

TRAIL

Involved in inducing cellular apoptosis

[41]

sTNF-RI

Involved in mediating the apoptotic effects of TNF-α

[42]

sTNF-RII

Involved in modulating T-cell proliferation

[42]

HSPs (60, 70, 90)

Mediators of an adaptive response to cellular stress

[43]

  1. Abbreviations: IL-1β, interleukin-1β; IL-1RA, interleukin-1 receptor antagonist; IL-4, interleukin-4; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; IL-17, interleukin-17; IL-18, interleukin 18; IFN- γ, interferon- γ; TNF-α, tumor necrosis factor-α; RANTES, Regulated upon Activation, Normal T-cell Expressed, and Secreted; MIP-1α, macrophage inflammatory protein-1α; GRO-α, growth-related oncogene-α; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; sTNF-R1, soluble tumor necrosis factor-α receptor-I; sTNF-RII, soluble tumor necrosis factor-α receptor-II; HSPs, heat shock proteins; NK, natural killer