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Table 1 Inflammatory mediators of interest

From: Assessment of the safety and feasibility of administering anti-pyretic therapy in critically ill adults: study protocol of a randomized trial

Mediator Role in Pyrexia or Inflammation Reference
IL-1β Potent endogenous pyrogen [30]
IL-1RA Endogenous anti-pyretic cytokine [31]
Il-4 Key mediator of humoral and adaptive immunity [32]
IL-6 Potent pro-inflammatory cytokine and pyrogen [30]
IL-8 Neutrophil chemotactic factor [33]
IL-10 Endogenous anti-pyretic cytokine [34]
IL-17 Potent pro-inflammatory mediator [35]
IL-18 Amplifies the innate immune response [36]
IFN-γ Endogenous pyrogen [30]
TNF-α Endogenous pyrogen and ubiquitous inflammatory mediator [37]
RANTES Chemotactic factor for T-cells, dendritic cells, and NK cells [38]
MIP-1α Leukocyte chemotactic factor [39]
GRO-α Neutrophil chemotactic factor [40]
TRAIL Involved in inducing cellular apoptosis [41]
sTNF-RI Involved in mediating the apoptotic effects of TNF-α [42]
sTNF-RII Involved in modulating T-cell proliferation [42]
HSPs (60, 70, 90) Mediators of an adaptive response to cellular stress [43]
  1. Abbreviations: IL-1β, interleukin-1β; IL-1RA, interleukin-1 receptor antagonist; IL-4, interleukin-4; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; IL-17, interleukin-17; IL-18, interleukin 18; IFN- γ, interferon- γ; TNF-α, tumor necrosis factor-α; RANTES, Regulated upon Activation, Normal T-cell Expressed, and Secreted; MIP-1α, macrophage inflammatory protein-1α; GRO-α, growth-related oncogene-α; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand; sTNF-R1, soluble tumor necrosis factor-α receptor-I; sTNF-RII, soluble tumor necrosis factor-α receptor-II; HSPs, heat shock proteins; NK, natural killer