Mediator | Role in Pyrexia or Inflammation | Reference |
---|---|---|
IL-1β | Potent endogenous pyrogen | [30] |
IL-1RA | Endogenous anti-pyretic cytokine | [31] |
Il-4 | Key mediator of humoral and adaptive immunity | [32] |
IL-6 | Potent pro-inflammatory cytokine and pyrogen | [30] |
IL-8 | Neutrophil chemotactic factor | [33] |
IL-10 | Endogenous anti-pyretic cytokine | [34] |
IL-17 | Potent pro-inflammatory mediator | [35] |
IL-18 | Amplifies the innate immune response | [36] |
IFN-γ | Endogenous pyrogen | [30] |
TNF-α | Endogenous pyrogen and ubiquitous inflammatory mediator | [37] |
RANTES | Chemotactic factor for T-cells, dendritic cells, and NK cells | [38] |
MIP-1α | Leukocyte chemotactic factor | [39] |
GRO-α | Neutrophil chemotactic factor | [40] |
TRAIL | Involved in inducing cellular apoptosis | [41] |
sTNF-RI | Involved in mediating the apoptotic effects of TNF-α | [42] |
sTNF-RII | Involved in modulating T-cell proliferation | [42] |
HSPs (60, 70, 90) | Mediators of an adaptive response to cellular stress | [43] |