Earlier-onset (n = 40) | Late-onset (n = 124) | P* | |
---|---|---|---|
Age | 50.2 ± 7.1 | 72.8 ± 8.4 | < 0.001 |
Sex (male) | 34 (85.0%) | 56 (45.2%) | < 0.001 |
Rs12425791 genotype (GA or AA) | 21 (52.5%) | 44 (35.5%) | 0.056 |
Rs11833579 genotype (GA or AA) | 28 (70.0%) | 57 (46.0%) | 0.008 |
Hypertension | 25 (62.5%) | 91 (73.4%) | 0.188 |
Diabetes mellitus | 15 (37.5%) | 53 (42.7%) | 0.558 |
Dyslipidemia | 31 (77.5%) | 79 (63.7%) | 0.107 |
Heart disease | 1 (2.5%) | 10 (8.1%) | 0.298† |
Smoking | 31 (77.5%) | 55 (44.4%) | < 0.001 |
Current smoking | 30 (75.0%) | 50 (41.3%) | < 0.001 |
Prior medication | |||
Antihypertensives | 11 (27.5%) | 52 (41.9%) | 0.103 |
Antidiabetics | 9 (22.5%) | 38 (30.6%) | < 0.001 |
Statins | 10 (25.0%) | 37 (29.8%) | 0.556 |
Antiplatelet | 8 (20.0%) | 23 (18.5%) | 0.838 |
Warfarin | 0 (0.00%) | 1 (0.81%) | 0.572 |
Ischemic stroke subtype‡ | 0.401† | ||
Large artery atherosclerosis | 11 (27.5%) | 36 (29.0%) | |
Small vessel occlusion | 22 (55.0%) | 62 (50.0%) | |
Cardioembolism | 2 (5.0%) | 4 (3.2%) | |
Other determined etiology | 1 (2.5%) | 0 (0%) | |
Undetermined etiology | 4 (10.0%) | 22 (17.7%) | |
Premorbid mRS | 0.6 ± 1.2 | 1.4 ± 1.8 | 0.001 |
Admission NIHSS | 3.1 ± 2.4 | 5.5 ± 5.9 | < 0.001 |
Discharge NIHSS | 1.7 ± 2.3 | 3.5 ± 4.6 | 0.002 |
NIHSS (Admission - Discharge) | 1.4 ± 2.8 | 2.0 ± 4.9 | 0.421 |
Discharge mRS | 1.4 ± 1.3 | 2.4 ± 1.7 | < 0.001 |
1 year mRS (n = 39 & 117) | 0.5 ± 0.8 | 2.0 ± 1.7 | < 0.001 |