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Table 1 Univariable analysis: factors associated with earlier-onset (< 59 years) vs.late-onset (≥ 59) first-ever ischemic stroke

From: NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions

 

Earlier-onset

(n = 40)

Late-onset

(n = 124)

P*

Age

50.2 ± 7.1

72.8 ± 8.4

< 0.001

Sex (male)

34 (85.0%)

56 (45.2%)

< 0.001

Rs12425791 genotype (GA or AA)

21 (52.5%)

44 (35.5%)

0.056

Rs11833579 genotype (GA or AA)

28 (70.0%)

57 (46.0%)

0.008

Hypertension

25 (62.5%)

91 (73.4%)

0.188

Diabetes mellitus

15 (37.5%)

53 (42.7%)

0.558

Dyslipidemia

31 (77.5%)

79 (63.7%)

0.107

Heart disease

1 (2.5%)

10 (8.1%)

0.298

Smoking

31 (77.5%)

55 (44.4%)

< 0.001

Current smoking

30 (75.0%)

50 (41.3%)

< 0.001

Prior medication

   

Antihypertensives

11 (27.5%)

52 (41.9%)

0.103

Antidiabetics

9 (22.5%)

38 (30.6%)

< 0.001

Statins

10 (25.0%)

37 (29.8%)

0.556

Antiplatelet

8 (20.0%)

23 (18.5%)

0.838

Warfarin

0 (0.00%)

1 (0.81%)

0.572

Ischemic stroke subtype

  

0.401

Large artery atherosclerosis

11 (27.5%)

36 (29.0%)

 

Small vessel occlusion

22 (55.0%)

62 (50.0%)

 

Cardioembolism

2 (5.0%)

4 (3.2%)

 

Other determined etiology

1 (2.5%)

0 (0%)

 

Undetermined etiology

4 (10.0%)

22 (17.7%)

 

Premorbid mRS

0.6 ± 1.2

1.4 ± 1.8

0.001

Admission NIHSS

3.1 ± 2.4

5.5 ± 5.9

< 0.001

Discharge NIHSS

1.7 ± 2.3

3.5 ± 4.6

0.002

NIHSS (Admission - Discharge)

1.4 ± 2.8

2.0 ± 4.9

0.421

Discharge mRS

1.4 ± 1.3

2.4 ± 1.7

< 0.001

1 year mRS (n = 39 & 117)

0.5 ± 0.8

2.0 ± 1.7

< 0.001

  1. Values are number (percentage) or mean ± standard deviation.
  2. *P for Student's t test or Chi-square test.
  3. Fisher's exact test.
  4. TOAST classification
  5. mRS and NIHSS denote modified Rankin scale and NIH stroke scale, respectively.