Identifying microRNA/mRNA dysregulations in ovarian cancer

Table 1 Anti-correlated and positively correlated mRNA/microRNA pairs in the tumour and/or the normal samples

microRNA	mRNA	normal	tumour	MicroRNA Regulation in tumour vs. normal	Gene Regulation in tumour vs. normal	P-value
hsa-miR-140-3p	RAD51AP1	-	-	Down	Up	0.002
hsa-miR-96	KIF23	none	-	Up	Up	0.006
hsa-miR-96	BIRC5	none	-	Up	Up	0.003
hsa-miR-140-3p	RACGAP1	none	-	Down	Up	0.012
hsa-miR-139-5p	RACGAP1	none	-	Down	Up	0.012
hsa-miR-133a	GCLC	none	-	Down	Down	0.023
hsa-miR-16	E2F3	none	-	Up	Up	0.027
hsa-miR-140-3p	C8ORF30A	none	-	Down	Up	0.022
hsa-miR-15b	C8ORF30A	none	-	Up	Up	0.011
hsa-miR-16	C8ORF30A	none	-	Up	Up	0.001
hsa-miR-16	SCAMP5	none	-	Up	Up	3.7E-4
hsa-miR-18a	DNAI1	none	-	Up	Down	0.038
hsa-miR-18b	DNAI1	none	-	Up	Down	0.014
hsa-miR-590-5p	E2F3	+	-	Up	Up	0.020
hsa-miR-34c-5p	E2F3	+	-	Down	Up	0.028
hsa-miR-16	CDC25C	+	+	Up	Up	0.016
hsa-miR-18a	GINS1	+	+	Up	Up	0.0
hsa-miR-18b	GINS1	+	+	Up	Up	0.0
hsa-miR-18a	RAD51AP1	none	+	Up	Up	6.1E-06
hsa-miR-18b	RAD51AP1	none	+	Up	Up	6.2E-07
hsa-miR-15b	RACGAP1	none	+	Up	Up	0.009

a) This Table lists the 21 mRNA/microRNA regulatory pairs found in ovarian tumour samples. The microRNA shown are also differentially expressed in tumour samples compared with normal, exhibit seed sequence complementarity in the gene shown, and are significantly anti-correlated (red) or positively correlated (blue) with the corresponding mRNA in the tumour samples. The third and fourth columns show the type of correlation (if present) within normal and tumour samples respectively. A "+" symbol represents a positive correlation, while "-" represents an anti-correlation, and "none" represents no significant correlation across the samples