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Table 2 Anti-correlated and positively correlated mRNA/microRNA pairs in the tumour and/or the normal samples

From: Identifying microRNA/mRNA dysregulations in ovarian cancer

microRNA

mRNA

normal

tumour

MicroRNA Regulation in tumour vs. normal

Gene Regulation in tumour vs. normal

P-value

hsa-miR-140-3p

RAD51AP1

-

-

Down

Up

0.021

hsa-miR-139-5p

DNAH9

-

None

Down

Down

0.036

hsa-miR-139-5p

TOP2A

-

None

Down

Up

0.009

hsa-miR-140-3p

GCLC

-

None

Down

Down

0.036

hsa-miR-145

E2F3

-

none

Down

Up

0.009

hsa-miR-139-5p

E2F3

-

none

Down

Up

0.009

hsa-miR-96

FAM64A

-

none

Up

Up

0.002

hsa-miR-590-5p

E2F3

+

-

Up

Up

0.036

hsa-miR-34c-5p

E2F3

+

-

Down

Up

0.036

hsa-miR-16

CDC25C

+

+

Up

Up

0.0

hsa-miR-18a

GINS1

+

+

Up

Up

0.036

hsa-miR-18b

GINS1

+

+

Up

Up

0.036

hsa-miR-590-5p

TOP2A

+

none

Up

Up

0.036

hsa-miR-590-5p

RAD51AP1

+

none

Up

Up

0.021

hsa-miR-18a

RAD51AP1

+

none

Up

Up

0.021

hsa-miR-18a

GCLC

+

none

Up

Down

0.036

hsa-miR-15b

E2F3

+

none

Up

Up

0.021

hsa-miR-18a

NUSAP1

+

none

Up

Up

0.036

hsa-miR-590-5p

GINS1

+

none

Up

Up

0.036

  1. b) This Table lists the 19 mRNA/microRNA regulatory pairs found in normal ovary samples. The microRNA shown are also differentially expressed in tumour samples compared with normal, exhibit seed sequence complementarity in the gene shown, and are significantly anti-correlated (red) or positively correlated (blue) with the corresponding mRNA in the normal samples. The third and fourth columns show the type of correlation (if present) within normal and tumour samples respectively. A "+" symbol represents a positive correlation, while "-" represents an anti-correlation, and "none" represents no significant correlation across the samples