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Table 2 Anti-correlated and positively correlated mRNA/microRNA pairs in the tumour and/or the normal samples

From: Identifying microRNA/mRNA dysregulations in ovarian cancer

microRNA mRNA normal tumour MicroRNA Regulation in tumour vs. normal Gene Regulation in tumour vs. normal P-value
hsa-miR-140-3p RAD51AP1 - - Down Up 0.021
hsa-miR-139-5p DNAH9 - None Down Down 0.036
hsa-miR-139-5p TOP2A - None Down Up 0.009
hsa-miR-140-3p GCLC - None Down Down 0.036
hsa-miR-145 E2F3 - none Down Up 0.009
hsa-miR-139-5p E2F3 - none Down Up 0.009
hsa-miR-96 FAM64A - none Up Up 0.002
hsa-miR-590-5p E2F3 + - Up Up 0.036
hsa-miR-34c-5p E2F3 + - Down Up 0.036
hsa-miR-16 CDC25C + + Up Up 0.0
hsa-miR-18a GINS1 + + Up Up 0.036
hsa-miR-18b GINS1 + + Up Up 0.036
hsa-miR-590-5p TOP2A + none Up Up 0.036
hsa-miR-590-5p RAD51AP1 + none Up Up 0.021
hsa-miR-18a RAD51AP1 + none Up Up 0.021
hsa-miR-18a GCLC + none Up Down 0.036
hsa-miR-15b E2F3 + none Up Up 0.021
hsa-miR-18a NUSAP1 + none Up Up 0.036
hsa-miR-590-5p GINS1 + none Up Up 0.036
  1. b) This Table lists the 19 mRNA/microRNA regulatory pairs found in normal ovary samples. The microRNA shown are also differentially expressed in tumour samples compared with normal, exhibit seed sequence complementarity in the gene shown, and are significantly anti-correlated (red) or positively correlated (blue) with the corresponding mRNA in the normal samples. The third and fourth columns show the type of correlation (if present) within normal and tumour samples respectively. A "+" symbol represents a positive correlation, while "-" represents an anti-correlation, and "none" represents no significant correlation across the samples