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Table 3 Summary of the number and location of human potential enhancer-blocking elements

From: DNA fragments binding CTCF in vitro and in vivo are capable of blocking enhancer activity

Cells Potential insulators (CTCF binding and enhancer- blocking sites) Intergenic Intronic or exonic Within ± 2 kb from promoter Technique used Ref.
IMR90 human fibroblasts 13804 46% 34% 20% ChIP-chip [10]
Resting human CD4+T-cells 28661 49% 36% 15% ChIP-Seq [9, 39]
HeLa 19308 56% 37% 7% ChIP-Seq [9]
Jurkat 19572 55% 36% 9% ChIP-Seq [9]
Mouse embryonic stem cells 39609 N/D N/D N/D ChIP-Seq [40]
HeLa/CHO 28 (84000/genome) 46% 36% 18% Positive- negative selection [11, 12]
  1. N/D-no data