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Table 2 Biological CVD risk indicators at baseline and follow-up and intervention effects from linear regression analyses, based on a complete-case analysis *

From: No significant improvement of cardiovascular disease risk indicators by a lifestyle intervention in people with Familial Hypercholesterolemia compared to usual care: results of a randomised controlled trial

  Control group Intervention group beta 95% CI
LDL-C (mmol/l, mean ± SD) Baseline 12 months Difference N = 105 3.7 (1.2) 3.6 (1.2) −0.1 N = 128 3.6 (1.3) 3.5 (1.1) −0.1 −0.20 −0.40-0.03
HDL-C (mmol/l, mean ± SD) Baseline 12 months Difference N = 143 1.2 (0.4) 1.2 (0.4) 0 N = 169 1.2 (0.4) 1.2 (0.4) 0 0.02 −0.04-0.08
TC (mmol/l, mean ± SD) Baseline 12 months Difference N = 146 5.2 (1.2) 5.1 (1.2) −0.1 N = 169 5.3 (1.4) 5.2 (1.2) −0.1 −0.04 −0.25-0.18
Triglycerides (mmol/l, mean ± SD) Baseline 12 months Difference N = 110 1.3 (0.7) 1.2 (0.6) −0.1 N = 128 1.2 (0.6) 1.3 (0.7) +0.1 0.08 −0.08-0.23
Systolic blood pressure (mmHg, mean ± SD) Baseline 12 months Difference N = 143 126.3 (15.7) 125.2 (14.4) −1.1 N = 169 123.0 (14.4) 123.0 (14.1) 0 0.003 −2.28-2.28
Glucose (mmol/l, mean ± SD) Baseline 12 months Difference N = 145 4.9 (1.0) 4.8 (0.8) −0.1 N = 169 4.9 (0.8) 4.7 (0.7) −0.2 −0.06 −0.19-0.07
BMI (kg/m2, mean ± SD) Baseline 12 months Difference N = 147 27.1 (5.4) 27.1 (5.2) 0 N = 167 25.9 (4.5) 25.8 (4.4) −0.1 −0.18 −0.43-0.07
Waist circumference (cm, mean ± SD) Baseline 12 months Difference N = 146 89.9 (14.5) 89.9 (14.3) 0 N = 165 86.4 (11.9) 86.1 (11.5) −0.3 −0.54 −1.45-0.40
  1. *Differences between control and intervention group after 12 months are tested through linear regression analyses, controlled for baseline values and baseline BMI. Beta = unstandardised regression coefficient; N = sample size; SD = standard deviation; 95% CI = 95% confidence interval as effect indicator from linear regression analyses; Means presented are from unadjusted analyses; Significant differences between control and intervention group (P < 0.05) printed in bold font. Only the results of the complete case analysis are presented, since no major differences were found between intention-to-treat analysis and complete case analysis.
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