Table 1 Medians and central 95% distribution of concentrations of steroids (ng/mL) in blood of apathetic children at the entry in the study and at the last follow-up

Illness Score

29.5 (22–35)

0 (0–1)

15.61 (<0.001)

Cortisol

101 (19–154)

103 (85–137)

0.081 (0.776)

Cortisone

25 (13–32)

28 (21–31)

3.12 (0.077)

Total Glucocorticoids

142 (32–201)

128 (91–170)

0.029 (0.870)

25 hydroxy vitamin D

10 (5–22)

12 (6–23)

0.925 (0.336)

Estrone

Girls

0.039 (0.012–0.19)

0.08 (0.01–0.087)

1.37 (0.242)

Boys

0.018 (0.003–0.039)

0.023 (0.005–0.024)

0.083 (0.773)

Estradiol

Girls

0.05 (0.01–0.26)

0.12 (0.008–0.17)

0.771 (0.380)

Boys

0.01 (0.01–0.041)

0.018 (0.006–0.024)

0.333 (0.564)

DHEA

Girls

5.0 (1.9–8.8)

4.2 (2.1–5.4)

0.343 (0.558)

Boys

2.6 (1.6–5.6)

3.3 (1.2–6.1)

0.083 (0.773)

Androstenedione

Girls

1.2 (0.6–2.4)

1.2 (0.6–1.6)

0.342 (0.545)

Boys

0.6 (0.2–1.1)

0.6 (0.2–1.3)

0.00 (1.00)

Testosterone

Girls

0.29 (0.2–0.5)

0.26 (0.15–0.39)

0.263 (0.608)

Boys

4.5 (0.1–7.0)

4.3 (0.04–5.9)

0.0833 (0.773)

Dihydrotestosterone

Girls

0.084 (0.003–0.088)

0.05 (0.03–0.066)

1.05 (0.307)

Boys

0.18 (0.03–2.24)

0.22 (0.015–0.29)

0.333 (0.563)

Pregnenolone

1.73 (0.55–3.78)

1.32 (0.7–2.62)

0.989 (0.319)

17OH-Pregnenolone

2.1 (0.5–5.8)

2.3 (1.0–4.5)

0.990 (0.319)

Allopregnenolone

0.07 (0.02–0.3)

0.07 (0.02–1.4)

0.005 (0.943)

Progesterone

Girls

0.28 (0.04–3.6)

0.39 (0.03–9.8)

0.021 (0.883)

Boys

0.11 (0.05–0.12)

0.07 (0.06–0.15)

0.0854 (0.770)

17OH-Progesterone

Girls

0.33 (0.21–1.0)

0.42 (0.22–0.85)

0.0215 (0.884)

Boys

0.64 (0.27–1.0)

0.52 (0.28–0.77)

0.333 (0.564)

11Deoxycortisol

0.5 (0.1–1.4)

0.6 (0.2–1.3)

0.021 (0.887)

Deoxycorticosterone

0.7 (0.5–2)

0.7 (0.3–1.5)

0.612 (0.434)

Corticosterone

4.9 (0.3–15.2)

3.8 (1.7–13.1)

0.00 (1.00)