Correlation between rate of nucleotide substitution ( K
) and percentage amino acid divergence. In-paralogs are denoted as squares, and out-paralogs are denoted as circles. Correlations between K
and amino acid divergence in in-paralogs and out-paralogs are shown in panel A and panel C, respectively. Also, correlations between K
and amino acid divergence in in-paralogs and in out-paralogs are shown in panel B and panel D, respectively.