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Table 4 ROC graphs parameters obtained for trace elements present in different tissues

From: Trace elements as tumor biomarkers and prognostic factors in breast cancer: a study through energy dispersive x-ray fluorescence

Group 1: Malignant (1) and normal adjacent tissues (0)-paired samples

Element

Best cut-off (mg.kg-1)

Sensitivity (%)

Specificity (%)

Area under ROC curve

p

Ca

580.9

55.2

93.1

0.757

0.001

Fe*

19.3

69.0

93.1

0.837

<0.001

Cu

1.0

55.2

82.8

0.740

0.002

Zn*

4.0

72.4

82.8

0.824

<0.001

Group 2: Malignant (1) and normal tissues (0)

Ca*

212.6

70.7

86.4

0.838

<0.001

Fe

12.6

78.0

63.6

0.743

<0.001

Cu

0.8

53.7

81.8

0.707

0.001

Zn*

3.4

75.6

86.4

0.874

<0.001

Group 3: Benign (1) and normal tissues (0)

Ca*

288.8

100.0

93.2

0.992

<0.001

Fe

12.8

66.7

63.6

0.616

0.276

Cu*

0.9

100.0

86.3

0.947

<0.001

Zn*

4.4

100.0

93.1

0.985

<0.001

Group 4: Benign (1) and malignant tissues (0)/Δ Benign (0) and malignant tissues(1)

Ca*

794.6

77.8

80.5

0.816

0.003

Fe Δ

20.7

48.7

88.8

0.675

0.103

Cu*

0.9

100.0

56.1

0.808

0.004

Zn

4.4

100.0

46.3

0.759

0.016

  1. The values 1 and 0 used in graphs construction represent tissues considered with presence and absence of disease, respectively. Elements highlight by * show area under the ROC curve higher than 0.8.