Table 5 Correlation between trace elements expression, tissue type and prognostic factors

Breast Tissue

Normal

33

5

22

16

29

9

31

7

Malignant

7

27

6

28

17

17

7

27

Benign

0

9

3

6

0

9

0

9

Normal Adjacent

11

14

13

12

16

9

17

8

p

<0.001

0.005

<0.001

<0.001

Age (years)

< 30

0

6

4

2

0

6

0

6

30–50

17

16

11

22

22

11

17

16

50–70

3

9

2

10

6

6

4

8

> 70

1

8

0

9

4

5

0

9

p

0.019

0.028

0.023

0.007

Menstrual status

Premenopausal

17

22

17

22

26

13

17

22

Postmenopausal

4

17

0

21

6

15

4

17

p

0.050

<0.001

0.005

0.05

Death

Yes

17

33

17

33

30

20

19

31

No

4

6

0

10

2

8

2

8

p

0.490

0.025

0.024

0.239

Tumor size (cm)

≤ 2

1

4

1

4

2

3

1

4

2–5

5

22

5

22

10

17

5

22

≤ 5

1

7

2

6

4

4

1

7

p

0.914

0.922

0.806

0.914

Histologic Grading (Bloom and Richardson)

G1

1

5

1

5

5

1

2

4

G 2

1

11

0

12

5

7

1

11

G 3

3

5

2

6

5

3

4

4

p

0.264

0.208

0.228

0.111

Pathologic staging

II

4

6

1

9

3

7

4

6

III

3

6

2

7

3

6

2

7

IV

0

1

0

1

0

1

1

0

p

0.719

0.69

0.788

0.271

Lymph nodes

Negative

2

9

2

9

8

3

2

9

1–3

0

4

0

4

2

2

0

4

≥ 3

5

10

3

12

6

9

5

10

p

0.330

0.626

0.253

0.33

Estrogen receptor

Negative

3

9

2

10

6

6

2

10

Positive

5

16

3

18

12

9

6

15

p

0.627

0.612

0.486

0.373

Progesterone receptor

Negative

2

11

2

11

7

6

2

11

Positive

6

14

3

17

11

9

6

14

p

0.299

0.669

0.614

0.299

HER2

score 0

3

9

3

9

10

2

5

7

score 1+

2

5

0

7

3

4

1

6

score 2+

1

7

0

8

2

6

1

7

score 3+

2

4

2

4

3

3

1

5

p

0.814

0.163

0.064

0.369