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Table 5 The Spearman correlations of the VAS results with the changes (%) from the initial lung function values in 36 subjects after inhaling histamine at the endpoint dose step (FEV 1 decrease ≥20%)

From: The relationship between inspiratory lung function parameters and airway hyper-responsiveness in subjects with mild to moderate COPD

  ∆ FEV1- VAS ∆FIV1- VAS ∆IC- ∆ FIF50- VAS ∆PIF-VAS
rS 0.12 -0.10 0.08 -0.33 -0.30
p-value 0.482 0.554 0.655 0.053 0.079
  1. Definition of abbreviations:
  2. FEV1 = forced expiratory volume in 1 second
  3. FIV1 = forced inspiratory volume in 1 second
  4. IC = inspiratory capacity (L)
  5. FIF50 = forced inspiratory flow at 50% of the vital capacity (L/s)
  6. PIF = peak inspiratory flow (L/s)
  7. ∆ = changes in initial values of lung function parameters when reaching the PD20 endpoint
  8. A higher VAS score denotes a higher degree of dyspnea