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Table 2 Functional enrichment in the regulatory hierarchy

From: Functional and topological characterization of transcriptional cooperativity in yeast

  Function  z -score  p -value
Layer-1 Biogenesis of cellular components −2.26 0.02
  Cell cycle and DNA processing −2.29 0.01
  Cell rescue, defense and virulence −4.16 1.58*10-5
  Cell type differentiation −3.28 5.18*10-4
  Cellular communication/signal transduction mechanism −2.1 0.01
  Cellular transport, transport facilities and transport routes 6.56 2.74*10-11
  Interaction with the environment −3.93 4.19*10-5
  Metabolism 4.67 1.51*10-6
  Protein with binding function or cofactor requirement −2.8 2.56*10-3
  Regulation of metabolism and protein function 6.1 5.47*10-10
Layer-2 Cell type differentiation 1.95 0.02
  Cellular transport, transport facilities and transport routes −2.18 0.01
  Interaction with the environment 2.28 0.01
Layer-3 Metabolism −1.95 0.02
  Regulation of metabolism and protein function −1.88 0.03
  Cell type differentiation −2.18 0.01
  Interaction with the environment −2.62 4.43*10-3
  Regulation of metabolism and protein function −1.81 0.03
  1. This table shows all significantly over-represented or under-represented functional categories for cooperative TFs in regulatory hierarchy. Negative z-scores mean under-representation, positive z-scores mean over-representation.