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Table 2 Functional enrichment in the regulatory hierarchy

From: Functional and topological characterization of transcriptional cooperativity in yeast

 

Function

 z -score

 p -value

Layer-1

Biogenesis of cellular components

−2.26

0.02

 

Cell cycle and DNA processing

−2.29

0.01

 

Cell rescue, defense and virulence

−4.16

1.58*10-5

 

Cell type differentiation

−3.28

5.18*10-4

 

Cellular communication/signal transduction mechanism

−2.1

0.01

 

Cellular transport, transport facilities and transport routes

6.56

2.74*10-11

 

Interaction with the environment

−3.93

4.19*10-5

 

Metabolism

4.67

1.51*10-6

 

Protein with binding function or cofactor requirement

−2.8

2.56*10-3

 

Regulation of metabolism and protein function

6.1

5.47*10-10

Layer-2

Cell type differentiation

1.95

0.02

 

Cellular transport, transport facilities and transport routes

−2.18

0.01

 

Interaction with the environment

2.28

0.01

Layer-3

Metabolism

−1.95

0.02

 

Regulation of metabolism and protein function

−1.88

0.03

 

Cell type differentiation

−2.18

0.01

 

Interaction with the environment

−2.62

4.43*10-3

 

Regulation of metabolism and protein function

−1.81

0.03

  1. This table shows all significantly over-represented or under-represented functional categories for cooperative TFs in regulatory hierarchy. Negative z-scores mean under-representation, positive z-scores mean over-representation.