Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer

Table 3 Breast cancer genes differentially expressed between CAW and AAW patient populations

Gene	Description	CAW^a	AAW^b	CAW/AAW^c	P-valued
*Genes Associated with Breast Cancer Prognosis*
AR	Androgen receptor	0.99	0.38	2.60	0.002
BCL2	B-cell CLL/lymphoma 2	0.65	0.20	3.28	0.010
CCND1	Cyclin D1	0.78	0.28	2.75	0.030
CDKN1A	Cyclin-dependent kinase inhibitor 1A	2.07	0.90	2.29	0.002
CDKN1B	Cyclin-dependent kinase inhibitor 1B	1.68	0.74	2.26	0.001
CDKN2A	Cyclin-dependent kinase inhibitor 2A	1.35	3.55	0.38	0.046
ERBB2	V-erb-b2 erythroblastic leukemia viral oncogene homolog 2	1.61	0.63	2.56	0.012
ESR1	Estrogen receptor 1	1.79	0.46	3.91	0.023
GATA3	GATA binding protein 3	1.57	0.17	9.33	0.001
IGFBP2	Insulin-like growth factor binding protein 2, 36 kDa	1.53	0.73	2.11	0.005
IL6ST	Interleukin 6 signal transducer	1.15	0.44	2.64	0.005
KRT19	Keratin 19	1.44	0.71	2.03	0.012
MUC1	Mucin 1, cell surface associated	1.77	0.36	4.94	0.004
PGR	Progesterone receptor	0.77	0.33	2.34	0.012
SERPINE1	Serpin peptidase inhibitor, clade E, member 1	7.59	3.18	2.38	0.014
*Genes Associated with Response to Chemotherapy*
HSPB1	Heat shock 27 kDa protein 1	0.98	0.46	2.14	0.003
SERPINA3	Serpin peptidase inhibitor, clade A, member 3	0.43	0.20	2.16	0.017
STC2	Stanniocalcin 2	0.79	0.38	2.05	0.019
*Genes Associated with Breast Cancer Progression*
CLDN7	Claudin 7	1.76	0.66	2.67	0.006
DLC1	Deleted in liver cancer 1	4.27	0.94	4.52	0.023

ISSN: 1756-0500