Table 4 Late-sequelae hazard ratios for different risk factors

Gender: Female (reference group)

1.00

Male

0.85

0.71–1.00

   0.06

Age: from 0 to 5 years (reference group)

1.00

From 5 to 10 years

0.65

0.51–0.84

<0.01

From 10 to 16 years

0.40

0.31–0.52

<0.01

Diagnosis period: 1957-1975 (reference group)

1.00

1976-1980

1.15

0.83–1.59

   0.41

1981-1985

1.22

0.89–1.68

   0.21

1986-1990

1.02

0.74–1.41

   0.89

1991-1995

0.90

0.63–1.28

   0.56

1996-2005

1.14

0.81–1.61

   0.45

Treatment: Surgery only (S, reference group)

1.00

Radiotherapy only (RT)

1.91

1.06–3.47

   0.03

Chemotherapy only (CHT)

0.96

0.53–1.74

   0.88

Surgery and Radiotherapy (S_RT)

3.25

2.31–4.57

<0.01

Surgery and Chemotherapy (S_CHT)

2.49

1.76–3.54

<0.01

Radio and Chemotherapy (RT_CHT)

2.29

1.54–3.40

<0.01

Surgery, Radio and Chemotherapy (S_RT_CHT)

3.80

2.71–5.32

<0.01

Primary diagnosis: Leukemia (reference group)

1.00

NHL

1.82

1.21–2.74

<0.01

Neuroblastoma

2.27

1.23–4.20

   0.01

Other malignant neoplasms

2.93

1.69–5.06

<0.01

Rhabdomyosarcoma

2.97

1.79–4.93

<0.01

HD

3.09

2.14–4.45

<0.01

CNS

3.60

2.33–5.55

<0.01

Soft-tissue sarcomas

4.00

2.51–6.38

<0.01

Malignant bone tumors

4.54

2.81–7.31

<0.01

Other carcinomas

4.62

2.73–7.84

<0.01

Renal tumors

6.02

3.71–9.76

<0.01