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Table 2 DNA damage in the exposed subjects with different genotypes of polymorphisms

From: XRCC1 Arg399Gln was associated with repair capacity for DNA damage induced by occupational chromium exposure

SNP

genotype

n

Olive tail moment

Tail length

Tail DNA%

Median

P25-P75

Median

P25-P75

Median

P25-P75

XRCC1 Arg399Gln

GG

70

0.93

0.58–1.79

9.74

6.89–18.14

3.25

1.94–5.58

GA

42

0.73

0.46–1.35

8.19

5.93–13.79

2.50

1.77–4.36

AA

8

0.50

0.43–0.93

6.64

5.00–9.92

1.91

1.43–3.03

 

P *

 

0.048

0.050

0.039

 

AA + GA

50

0.66

0.44–1.31

8.00

5.69–13.74

2.32

1.66–4.33

 

P ∮

 

0.043

0.067

0.046

XRCC1 Arg194Trp

CC

66

0.75

0.47–1.45

8.55

6.30–14.22

2.82

1.66–4.85

CT

49

0.91

0.48–1.49

9.69

6.97–16.25

3.22

1.83–4.75

TT

5

0.66

0.37–1.82

7.67

5.11–16.94

2.39

1.29–5.84

 

P *

 

0.973

0.964

0.992

OGG1 Ser326Cys

CC

18

1.09

0.41–1.84

11.72

4.92–18.87

3.63

1.55–5.80

CG

56

0.86

0.47–1.46

9.18

6.50–15.53

3.07

1.73–4.86

GG

41

0.78

0.56–1.19

8.93

6.87–12.07

2.69

2.02–4.15

 

P *

 

0.462

0.335

0.377

ERCC1 C8092A

CC

20

0.84

0.45–1.38

9.79

6.56–15.53

3.20

1.77–4.72

CA

47

0.71

0.47–1.43

8.10

5.81–14.10

2.45

1.61–4.53

AA

49

0.92

0.62–1.60

9.66

7.21–17.29

3.22

2.06–5.50

 

P *

 

0.543

0.690

0.595

ERCC5 His1104Asp

GG

25

0.92

0.62–1.60

9.66

7.21–17.29

3.22

2.06–5.50

GC

61

0.84

0.54–1.50

9.66

6.79–15.88

2.84

1.99–4.99

CC

30

0.83

0.50–1.38

9.21

7.01–15.05

3.04

1.81–4.59

 

P *

 

0.886

0.931

0.920

ERCC6 Gly399Asp

CC

32

0.83

0.49–1.14

8.90

6.82–11.70

3.03

1.87–3.97

CT

54

0.75

0.48–1.73

8.26

6.42–16.12

2.75

1.85–5.51

TT

31

1.03

0.48–1.57

10.70

5.72–18.10

3.22

1.68–5.19

 

P *

 

0.143

0.152

0.203

XPD Lys751Gln

AA

94

0.82

0.48–1.45

9.50

6.42–14.84

2.94

1.81–4.80

AC

20

0.81

0.48–1.81

8.79

7.00–16.74

2.88

1.88–5.81

CC

0

      
 

P *

 

0.771

0.742

0.900

XPC Lys939Gln

GG

45

0.89

0.56–1.52

9.66

6.97–15.96

2.96

2.02–5.14

GT

53

0.83

0.47–1.40

8.87

6.63–14.07

2.75

1.39–6.13

TT

18

0.81

0.39–2.10

9.13

5.68–23.00

2.92

1.73–4.57

 

P *

 

0.564

0.379

0.705

GSTP1 Ile105Val

AA

80

0.83

0.52–1.58

9.21

6.75–15.65

2.94

1.85–5.30

AG

30

0.70

0.38–1.41

8.03

5.71–15.29

2.41

1.62–4.53

GG

6

1.02

0.71–1.84

11.89

8.83–18.95

3.74

2.46–5.83

 

P *

 

0.169

0.514

0.463

  1. * The DNA damage data was square root-transformed and multivariable linear model was used after adjusting confounding factors of gender, age, smoking status, drinking and exposure time of chromium.
  2. Comparing the subjects with GG genotype with AA + GA.
  3. ∫ Owing to missing detect in DNA damage and genotype, the numbers of subjects in Table 2 were less 157 in exposed group.
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BMC Research Notes

ISSN: 1756-0500

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