Skip to main content

Table 2 DNA damage in the exposed subjects with different genotypes of polymorphisms

From: XRCC1 Arg399Gln was associated with repair capacity for DNA damage induced by occupational chromium exposure

SNP genotype n Olive tail moment Tail length Tail DNA%
Median P25-P75 Median P25-P75 Median P25-P75
XRCC1 Arg399Gln GG 70 0.93 0.58–1.79 9.74 6.89–18.14 3.25 1.94–5.58
GA 42 0.73 0.46–1.35 8.19 5.93–13.79 2.50 1.77–4.36
AA 8 0.50 0.43–0.93 6.64 5.00–9.92 1.91 1.43–3.03
  P *   0.048 0.050 0.039
  AA + GA 50 0.66 0.44–1.31 8.00 5.69–13.74 2.32 1.66–4.33
  P   0.043 0.067 0.046
XRCC1 Arg194Trp CC 66 0.75 0.47–1.45 8.55 6.30–14.22 2.82 1.66–4.85
CT 49 0.91 0.48–1.49 9.69 6.97–16.25 3.22 1.83–4.75
TT 5 0.66 0.37–1.82 7.67 5.11–16.94 2.39 1.29–5.84
  P *   0.973 0.964 0.992
OGG1 Ser326Cys CC 18 1.09 0.41–1.84 11.72 4.92–18.87 3.63 1.55–5.80
CG 56 0.86 0.47–1.46 9.18 6.50–15.53 3.07 1.73–4.86
GG 41 0.78 0.56–1.19 8.93 6.87–12.07 2.69 2.02–4.15
  P *   0.462 0.335 0.377
ERCC1 C8092A CC 20 0.84 0.45–1.38 9.79 6.56–15.53 3.20 1.77–4.72
CA 47 0.71 0.47–1.43 8.10 5.81–14.10 2.45 1.61–4.53
AA 49 0.92 0.62–1.60 9.66 7.21–17.29 3.22 2.06–5.50
  P *   0.543 0.690 0.595
ERCC5 His1104Asp GG 25 0.92 0.62–1.60 9.66 7.21–17.29 3.22 2.06–5.50
GC 61 0.84 0.54–1.50 9.66 6.79–15.88 2.84 1.99–4.99
CC 30 0.83 0.50–1.38 9.21 7.01–15.05 3.04 1.81–4.59
  P *   0.886 0.931 0.920
ERCC6 Gly399Asp CC 32 0.83 0.49–1.14 8.90 6.82–11.70 3.03 1.87–3.97
CT 54 0.75 0.48–1.73 8.26 6.42–16.12 2.75 1.85–5.51
TT 31 1.03 0.48–1.57 10.70 5.72–18.10 3.22 1.68–5.19
  P *   0.143 0.152 0.203
XPD Lys751Gln AA 94 0.82 0.48–1.45 9.50 6.42–14.84 2.94 1.81–4.80
AC 20 0.81 0.48–1.81 8.79 7.00–16.74 2.88 1.88–5.81
CC 0       
  P *   0.771 0.742 0.900
XPC Lys939Gln GG 45 0.89 0.56–1.52 9.66 6.97–15.96 2.96 2.02–5.14
GT 53 0.83 0.47–1.40 8.87 6.63–14.07 2.75 1.39–6.13
TT 18 0.81 0.39–2.10 9.13 5.68–23.00 2.92 1.73–4.57
  P *   0.564 0.379 0.705
GSTP1 Ile105Val AA 80 0.83 0.52–1.58 9.21 6.75–15.65 2.94 1.85–5.30
AG 30 0.70 0.38–1.41 8.03 5.71–15.29 2.41 1.62–4.53
GG 6 1.02 0.71–1.84 11.89 8.83–18.95 3.74 2.46–5.83
  P *   0.169 0.514 0.463
  1. * The DNA damage data was square root-transformed and multivariable linear model was used after adjusting confounding factors of gender, age, smoking status, drinking and exposure time of chromium.
  2. Comparing the subjects with GG genotype with AA + GA.
  3. ∫ Owing to missing detect in DNA damage and genotype, the numbers of subjects in Table 2 were less 157 in exposed group.