Figure 1

A) MtDNA content in control, typical hyperplasia, atypical hyperplasia and cancer. MtDNA content has been measured as mtDNA/nDNA ratio. Bars represent the average ± standard deviation of values obtained from different samples analysed in triplicate in 3–4 experiments. n, number of analysed samples. B) Citrate synthase activity in control, typical hyperplasia, atypical hyperplasia and cancer. Measurements of citrate synthase activity (μmoli x min^-1x g tissue^-1) were performed in cellular homogenate. Bars represent the average ± standard deviation of values obtained from different samples analysed in triplicate in 3 different experiments. *p < 0.05 and **p < 0.001 statistically significant differences versus control. § p < 0.05 statistically significant difference versus cancer.