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Figure 8 | BMC Research Notes

Figure 8

From: Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops

Figure 8

Oscillations in S2n. Oscillations in the MAPK cascade with underlying feedback design PN-II were terminated due to induction of its nuclear phosphatase P3-n. (A) Oscillations in MK** and MK**-n were abolished when P3 dephosphorylated MK** in the cytoplasm and P3-n dephosphorylated MK**-n in the nucleus. (B) Oscillations were not observed when P3 was knocked out (P3 = 0) and when only P3-n dephosphorylated MK**-n and MK*-n in the nucleus (C) For P3 = 0 throughout the simulations, and P3-n production stopped at time = 600 seconds, oscillations were not observed for any value of P3-n concentration. (D) When P3 was set to zero as initial condition and P3-n production was stopped at 600 seconds, followed by reverting P3 concentration back to its reference value (P3 = 500 nM) at 10000 seconds, sustained oscillations in both MK** and MK**-n were observed.

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