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Figure 9 | BMC Research Notes

Figure 9

From: Oscillations in MAPK cascade triggered by two distinct designs of coupled positive and negative feedback loops

Figure 9

Sensitivity of MK** in S1 and S2 and MK**-n in S1n and S2n to small perturbations in the system parameters. The kinetic parameters and signal strength ‘Sig’ of both S1 and S2 were subjected to small perturbations and sensitivity of MK** (in S1 and S2) and MK**-n (in S1n and S2n) to such perturbations were calculated. (A) Response of MK** of the system S1 to the perturbations in kinetic parameters. (B) Response of MK** of the system S2 to the perturbations in kinetic parameters. (C) Response of MK**-n of the system S1n to the perturbations in kinetic parameters and (D) Response of MK**-n of the system S2n to the perturbations in kinetic parameters. The parameters perturbed are in the X axis and sensitivity of MK** (MK**-n) to such perturbations is shown in the Y axis. Only the most sensitive parameters and ‘Sig’ are shown. List of all the parameters of S1 and S2 subjected to perturbation are shown in Additional file2: Table S1 with their respective values. List of all the parameters of S1n and S2n subjected to perturbation are listed in Table3 of the main text.

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