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Table 4 Minimal inhibitory concentration (MIC) in μg/ml of antibiotics in the absence and presence sub-inhibitory concentrations of Aframomum citratum extract against some MDR bacteria

From: Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes

Bacterial strains Antibiotics and MIC in absence and presence ofAframomum citratum extract
Ampicillin Cefepime Chloramphenicol Ciprofloxacin Cloxacillin
Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5
AG100Atet - - - - - - 256 32 (8) S 64 (4) S 256 128 (2) S 256 (1) I - - -
AG102 - - - 128 128 (1) I 128 (1) I 16 8 (2) S 8 (2) S <2 <2 <2 - - -
CM64 - 256 (1)I - - 64 (>4) S - nt nt nt nt nt nt - - -
KP63 - 32 (>8)S - 256 32 (8) S 256 (1) I - 64 (>4) S 256 (>1)S 64 64 (1) I 64 (1) I - 256 (>1)S -
PA124 128 16 (8) S 64 (2) S 128 128 (1) I 256 (0.5) I 32 16 (2) S 16 (2) S 16 4 (4) S 16 (1) I - - -
Bacterial strains Erythromycin Kanamycin Norfloxacin Streptomycin Tetracyclin
Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5 Alone MIC/2.5 MIC/5
AG100Atet 64 16 (4) S 32 (2) S - 32 (>8)S 256 128 16 (8) S 128 (1) I <2 <2 <2 2 <2 (>1)S 2 (1) I
AG102 32 16 (2) S 16 (2) S <2 <2 <2 <2 <2 <2 - 128 (>2)S 256 (>1)S <2 <2 <2
CM64 - 128 (>2)S 256 (>1)S 4 <2 <2 4 <2 (>2)S 4 (1) I 32 4 (8) S 8 (4) S nt nt nt
KP63 16 <1 (>16)S 4 (4) S 32 16 (2) S 32 (1) I - 128 (>2)S 256 (>1)S <4 <4 <4 <2 <2 <2
PA124 128 64 (2) S 64 (2) S 128 16 (8) S 64 (2) S 64 8 (8) S 32 (2) S nt nt nt 8 2 (4) S 2 (4) S
  1. MIC/2.5: concentration of plant extract added equal to 204.8 μg/mL for AG100ATET. KP63; and to 409.6 μg/mL for PA124. CM64. AG102.
  2. MIC/5: concentration of plant extract added equal to 102. 4 μg/mL for AG100ATET. KP63; and to 204.8 μg/mL for PA124. CM64. AG102.
  3. (): Folds decreasing of MIC. S: synergy. I: indifference. nt: not tested; (−): MIC > 256.