GROUP | AUC (x105) | Ptotal(x106) | Pmax(x106) | DAY OFPmax | P8thDI(x106) | 2nd Pmax(x104) | DAY OF 2nd PEAK | 2nd PEAK n/N (%) |
|---|
CI | 10.9±8.20 | 12.5±8.98 | 5.02±7.07 | 10.76±3.15 | 2.82±3.12 | 11.0±10.2 | 14.03±2.63 | 8/12 (66%) |
BIOT4-5-6 | 9.23±3.26 | 9.33±3.25 | 5.82±2.14** | 8.25±0.67** | 5.11±2.62 | 2.10±17.4 | 12.0±2.0* | 4/12 (33%) |
BIOT7-8-9 | 8.78±2.34 | 9.32±2.48 | 4.05±2.42 | 8.64±0.71** | 3.96±2.51 | 17.4±0 | 14.25±1.02 | 8/12 (66%) |
BIOTPI | 5.95±4.55** | 6.63±5.02** | 2.25±1.65** | 15.46±23.06 | 1.62±1.69 | 11.1±13.6 | 13.67±0.63* | 6/12 (50%) |
BIOT4PI | 4.28±2.89** | 4.63±3.19** | 1.45±1.00** | 10.27±2.03 | 1.01±0.96 | 7.09±10.2 | 12.8±0.68* | 6/12 (50%) |
- Statistical significance (p < 0.05* and p < 0.01**) compared to control group: CI: control group – infected animals treated with 7% ethanol-water solution diluted in water (10μL/mL) offered ad libitum; BIOTPI: infected animals treated with biotherapic BIOTTc 17dH diluted in water (10μL/mL) offered ad libitum from the day of the infection until the death of the animals; BIOT4PI: infected animals treated with biotherapic BIOTTc 17dH diluted in water (10μL/mL) offered ad libitum from the 4th day of the infection until the death of the animals; BIOT4-5–6: infected animals treated with biotherapic BIOTTC 17dH by gavage on the 4th, 5th and 6th day of the infection; BIOT7-8–9: infected animals treated with biotherapic BIOTTC 17dH by gavage on the 7th, 8th and 9th day of the infection. AUC = area under the curve (parasites/ mL); Ptotal = total parasitemia (parasites/ mL); Pmax = maximum peak of parasites (parasites/ mL); Day of Pmax = Day of maximum peak of parasites; P8thDI = number of tripomastigotes on 8th day of infection (parasites/ mL); 2nd Pmax = number of tripomastigotes in the 2nd peak of parasites (parasites/ mL); Day of 2nd Pmax = Day of 2nd peak of parasites; 2ndPEAK n/N = number of animals that showed 2nd peak of parasites (n)/ total number of infected animals (N) x 100.
