Highly diluted medication reduces parasitemia and improves experimental infection evolution by Trypanosoma cruzi

Table 2 Prepatent period (PPP), patent period (PP), survival and percent mortality of animals subjected to different treatment schemes using biotherapic (BIOT _{Tc
17dH} )

GROUP	PPP (days)	PP (days)	SURVIVAL (days)	DEATH n/N (%)
CI	6.02±1.85	9.63±2.74	15.33±3.39	12/12 (100%)
BIOT_4-5-6	3.86±1.36*	7.43±1.99*	12.14±1.25*	12/12 (100%)
BIOT_7-8-9	4.38±1.32*	8.88±1.62	14±1.5	12/12 (100%)
BIOT_PI	13.67±33.11	6.61±2.69**	29±42.79	10/12 (83%)
BIOT_4PI	21.5±42.87**	5.78±1.03**	27.1±40.98**	11/12 (92%)

Statistical significance (p < 0.05* and p < 0.01**) compared to control group: CI: control group – infected animals treated with 7% ethanol-water solution diluted in water (10μL/mL) offered ad libitum; BIOT_PI: infected animals treated with biotherapic BIOT_{Tc 17dH} diluted in water (10μL/mL) offered ad libitum from the day of the infection until the death of the animals; BIOT_4PI: infected animals treated with biotherapic BIOT_{Tc 17dH} diluted in water (10μL/mL) offered ad libitum from the 4^th day of the infection until the death of the animals; BIOT_4-5–6: infected animals treated with biotherapic BIOT_{TC 17dH} by gavage on the 4^th, 5^th and 6^th day of the infection; BIOT_7-8–9: infected animals treated with biotherapic BIOT_{TC 17dH} by gavage on the 7^th, 8^th and 9^th day of the infection.

ISSN: 1756-0500