The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

Table 3 Allelic positivities of single nucleotide polymorphisms (SNPs) in the TLR4 gene in Japanese subjects.

dbSNP*	Location Position	Allele	Emphysema (N = 106)	Controls (N = 137)	O.R.	P
			Allelic Positivity n (%)
rs10759930	promoter 119,501,442	T C	92 (86.8) 62 (58.5)	111 (81.0) 83 (60.6)	1.54 0.92	0.229 0.741
rs1927914	promoter 119,504,546	A G	92 (86.8) 62 (58.5)	111 (81.0) 83 (60.6)	1.54 0.92	0.229 0.741
rs12377632	intron 2 119,512,551	C T	92 (86.8) 61 (57.5)	111 (81.0) 82 (59.9)	1.54 0.91	0.229 0.717
rs2149356	intron 2 119,514,020	G T	93 (87.7) 61 (57.5)	111 (81.0) 82 (59.9)	1.68 0.91	0.157 0.717
rs11536889	3'UTR 119,517,952	G C	88 (83.0) 58 (54.7)	127 (92.7) 58 (42.3)	0.38 1.65	0.019 0.055
rs7037117	3'UTR 119,523,484	A G	102 (96.2) 44 (41.6)	133 (97.1) 51 (37.2)	0.77 1.20	0.711 0.497
rs7045953	3'UTR 119,525,616	A G	106 (100) 18 (17.0)	137 (100) 21 (15.3)	- 1.13	- 0.728

Subjects included patients with emphysema and control smokers
*SNP designations are from the NCBI SNP database [29]. N = number of subjects. n = number of present alleles
P values were calculated with χ² tests of 2 × 2 contingency table

ISSN: 1756-0500