The association of Toll-like receptor 4 gene polymorphisms with the development of emphysema in Japanese subjects: a case control study

Table 4 Allelic frequency and genotypic distribution of the rs11536889 in the TLR4 gene in emphysema and control groups

rs11536889	Type	Emphysema (N = 106)	Controls (N = 137)	O.R.	P	P ^a
Allelic frequency, n (%)	G	136(64.2)	206 (75.2)	0.59	0.0083
	C	76 (35.8)	68 (24.8)	1.69*
Genotypic distribution, n (%)	GG	48 (45.3)	79 (57.7)	0.61	0.055
	GC	40 (37.7)	48 (35.0)	1.12	0.664	0.034
	CC	18 (17.0)	10 (7.3)	2.60^‡	0.019

N number of subjects. n number of present alleles or genotypes correspondingly
P and P^a values were calculated with χ² tests of 2 × 2 and 3 × 2 contingency tables, respectively
*Odds Ratio = 1.69, 95% Confidence Intervals = 1.14-2.50
^‡Odds Ratio = 2.60, 95% Confidence Intervals = 1.17-5.78

ISSN: 1756-0500