Figure 3

Genes that associate most strongly with the OXPHOS expression phenotype are mitochondria-associated. A) The 100 most strongly correlated genes with the MOOTHA_VOXPHOS gene set (OXPHOS gene set correlations) as compared to known electron transport subunit genes (OXPHOS genes, see Main Text) and mitochondrial-associated genes from the Mitocarta compendium. Genes were filtered to only include those that were interrogated in the gene expression array data. Nineteen genes associated with MOOTHA_VOXPHOS were not associated with Mitocarta or known mitochondrial subunit genes. B) The Gene Ontology classifications of the 19 OXPHOS gene set correlation genes described in A. C) Rank plot showing the top 100 OXPHOS-correlated genes described in A versus the predictions made by Baughman et al.[48]. Also shown are the GO associations of 10 of the 100 OXPHOS-correlated genes that were ranked lower by Baughman et al (a-j).