Enrichment scores of gene sets are related to the gene’s known biological role. A) The ranks of the strongest-correlated gene sets with similar characteristics to the known biological roles of genes highlighted in the book Genome. References are listed below. B) Plot of the HTT gene expression profile across all samples (green line, running median window size=11) compared to the median-centered fold-change expression for all genes of the most strongly correlated gene set, GCM_LTK (black lines: Q1= first quartile, Q3 = third quartile, heatmap: N=41). C) Plot of the ABO gene expression profile across all samples (orange line, running median window size=11), compared to the median-centered fold-change expression for all genes of the most strongly correlated gene set, VOLTAGE_GATED_CHANNEL_ACTIVITY (black lines: Q1= first quartile, Q3= third quartile, heatmap: N= 72). D) Genes from the book Genome with poorly- or broadly-characterized roles and the top five ranking gene sets by correlation coefficients for each gene are listed. In A and D, gene sets were listed according to their relative ranking (i.e. distance from the mean of the null distribution) and “DN” gene sets with negative correlations are shown in italics. Uninformative cancer gene modules were not included. References for part A: a, b, c, d, e, f, g, h, I, j, k, l, m, n, o, p, q, r, s, t, u, v, w.