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Table 3 Cytokine and immune mediator concentrations (pg/ml) in amniotic fluid obtained during the second and third trimester – univariate analysis

From: Influence of maternal age, gestational age and fetal gender on expression of immune mediators in amniotic fluid

Mediator Median concentration in pg/ml (range) Second trimester Median concentration in pg/ml (range) Third trimester p-value
IL-2 (n = 66) 2.1 (1.8-4.6) 4.5 (0.8-9.1) 0.054
IL-4 (n = 182) 10.0 (2.6-12.3) 7.1 (0.8-21.9) 0.022
IL-6 (n = 156) 1141.5 (91.2-2823) 764.2 (120.8-21275.0) 0.953
IL-8 (n = 185) 1035.1 (235.7-4295.8) 628.8 (0–17125.0) 0.111
IL-10 (n = 161) 4.9 (2.2-26.6) 6.6 (2.4-85.7) 0.037
IL-12 (n = 161) 4.8 (2.7-10.9) 6.8 (2.0-23.8) 0.038
IL-15 (n = 173) 15.4 (2.4-32.9) 35.0 (2.6-169.5) 0.109
IL-17 (n = 66) 17.5 (4.6-42.4) 23.1 (3.9-46.0) 0.645
TNF- α (n = 161) 22.1 (2.7-68.7) 10.5 (4.8-659.0) 0.001
GRO- α (n = 184) 248.8 (11.6-7029.7) 1252.3 (21.3-1658.8) 0.003
Pro IL1-ß (n = 157) 20.3 (15.2-43.2) 16.5 (0–8048.8) 0.16
Histone (n = 161) 0.15 (0.05-0.55) 0.29 (0.04-78.39) 0.156
IP-10 (n = 169) 1042.5 (574.4-2696.1) 681.3 (5.4-5184.9) 0.100
MIP1-ß (n = 182) 116.1 (16.1-485.2) 25.9 (5.9-16305.8) 0.001
MIP1- α (n = 186) 23.2 (13.8-153.2) 26.2 (0–1531.3) 0.818