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Table 3 Cytokine and immune mediator concentrations (pg/ml) in amniotic fluid obtained during the second and third trimester – univariate analysis

From: Influence of maternal age, gestational age and fetal gender on expression of immune mediators in amniotic fluid

Mediator

Median concentration in pg/ml (range) Second trimester

Median concentration in pg/ml (range) Third trimester

p-value

IL-2 (n = 66)

2.1 (1.8-4.6)

4.5 (0.8-9.1)

0.054

IL-4 (n = 182)

10.0 (2.6-12.3)

7.1 (0.8-21.9)

0.022

IL-6 (n = 156)

1141.5 (91.2-2823)

764.2 (120.8-21275.0)

0.953

IL-8 (n = 185)

1035.1 (235.7-4295.8)

628.8 (0–17125.0)

0.111

IL-10 (n = 161)

4.9 (2.2-26.6)

6.6 (2.4-85.7)

0.037

IL-12 (n = 161)

4.8 (2.7-10.9)

6.8 (2.0-23.8)

0.038

IL-15 (n = 173)

15.4 (2.4-32.9)

35.0 (2.6-169.5)

0.109

IL-17 (n = 66)

17.5 (4.6-42.4)

23.1 (3.9-46.0)

0.645

TNF- α (n = 161)

22.1 (2.7-68.7)

10.5 (4.8-659.0)

0.001

GRO- α (n = 184)

248.8 (11.6-7029.7)

1252.3 (21.3-1658.8)

0.003

Pro IL1-ß (n = 157)

20.3 (15.2-43.2)

16.5 (0–8048.8)

0.16

Histone (n = 161)

0.15 (0.05-0.55)

0.29 (0.04-78.39)

0.156

IP-10 (n = 169)

1042.5 (574.4-2696.1)

681.3 (5.4-5184.9)

0.100

MIP1-ß (n = 182)

116.1 (16.1-485.2)

25.9 (5.9-16305.8)

0.001

MIP1- α (n = 186)

23.2 (13.8-153.2)

26.2 (0–1531.3)

0.818