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Figure 3 | BMC Research Notes

Figure 3

From: Luminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype

Figure 3

The relationship of subtypes to the DNA ploidy and CIN. The diploid/CIN- status was detected in 72 (64.9%) of the 111 luminal A carcinomas, 39 (41.1%) of the 95 luminal B (HER2-) carcinomas, 8 (11.6%) of the 69 lumminal B (HER2+) carcinomas, 2 (4.9%) of the 41 HER2 carcinomas, and 8 (17.0%) of the 26 basal-like carcinomas. In contrast, the aneuploid/CIN + status was detected in 31 (27.9%) of the 111 luminal A, 47 (49.5%) of the luminal B (HER2-), 56 (81.2%) of the 69 luminal B (HER2+), 37 (90.2%) of the 41 HER2, and 36 (86.6%) of the 47 basal-like subtype tumors. The incidence of diploid/CIN- and aneuploid/CIN+ status was different between the luminal A subtype and luminal B (HER2-), luminal B (HER2+), HER2, and basal-like subtypes (p = 0.0006, p = 5E-13, p = 5E10-12, and p = 8E10-9). In addition, the incidence of diploid/CIN- and aneuploid/CIN+ status was statistically different between the luminal B (HER2-) subtype and luminal B (HER2+), HER2, and basal-like subtypes (p = 0.00002, p = 0.000009, and p = 0.002). Black bar; diploid/CIN- tumors, gray bar; aneuploid/CIN+ tumors, white column; others.

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