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Table 1 The status of genomic and cell proliferation markers in the ICH-based subtypes

From: Luminal A and luminal B (HER2 negative) subtypes of breast cancer consist of a mixture of tumors with different genotype

Markers

LumWalA

Luminal B, HER2-

Luminal B, HER2+

HER2

Basal-hke

Total

No. of tumors

111 (30.6%)

95 (26.2%)

69 (19.0%)

41 (11.3%)

47 (12.9%)

363

Age (range)

58.6 (34ā€“84)

54.8 (27ā€“84)

54.7 (30ā€“78)

58,9 (38ā€“87)

56.8 (31ā€“84)

56.7

Ki-67c14%

111 (100%)

0 (0%)

10 (14.5%)

1 (24.3%)

4 (8.5%)

126 (34.7%)

K6714%

0 (0%)

95 (100%)

59 (85.5%)

40 (97.8%)

43 (91.5%)

237 (65.3%)

DiploEd

78 (70.3%)

44 (46.3%)

11 (15.9%)

3 (7.3%)

8 (17.0%)

140 (38.6%)

Aneuploid

33 (29.7%)

51 (53.7%)

58 (84.1%)

38 (92.7%)

39 (83.0%)

223 (61.4%)

CIN-

74 (66.7%)

43 (45.3%)

10 (14.5%)

3 (7.3%)

10 (21.3%)

140 (38.6%)

CIN.

37 (33.3%)

52 (54.7%)

59 (85.5%)

38 (92.7%)

37 (787%)

223 (61.4%)

DipIod!ClN-

72 (64.9)

39 (41.1%)

8 (11.6%)

2 (4.9%)

8 (17.0%)

129 (35.5%)

AneuplodiClN+

31 (27.9%)

47 (49.5%)

56 (81.2%)

372 (90.2%)

36 (76.6%)

207 (57.0%)

Grade 1

53 (47.7%)

15 (15.8%)

6 (8.7%)

0 (0%)

4 (8.5%)

78 (20.4%)

Grade 2

32 (28.8%)

23 (24.2%)

10 (14.5%)

2 (4.9%)

2 (4.3%)

69 (19.0%)

Grade 3

20 (18.0%)

56 (58.9%)

52 (58.9%)

38 (92.7%)

40 (85.1%)

206 (57.3%)

nd

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  1. The numbers in the table indicate the number of tumors fitting each item. The numbers in parenthesis are the percentages of tumors fitting each hem. Ki-67+; tumors with a high Ki-67 index, Ki-67-; tumors with a ow Ki-67 index, CIN-; the absence of chromosomal instability, CIN+; the presence of chromosomal instability, Dip/CIN-IKi-67+; tumors with diploidiClN -IKi-67- features, Aneup/CINĆ·/Ki-67Ć·; tumors.