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Table 4 Conjugational transfer of multidrug resistance phenotypes in E. coli

From: High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal

Donor Transconjugant cMIC (μg/ml) of antibiotics towards donors and transconjugants aConjugation frequency
Resistance pattern Plasmid (kb) bESBL activity Resistance pattern Plasmid (kb) bESBL activity   Am C Cf Cfx G Nx Co  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, C
32.5 - Am, Cf, Cfx, Co, Of, Nx 32.5 - D > 512   > 256 > 512   128 512 0.3 × 10-7
       T > 512   64 > 512   64 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, C, G, Ci
32.5 + Am, Cf, Cfx, Co, Of, Nx 32.5 + D > 512   > 256 > 512   > 256 > 512 0.6 × 10-7
       T > 512   64 512   64 > 512  
Am, Cf, Co, Nx, Na, Of, Ca, Ci 32.5 + Am, Cf, Cfx, Co, Of, Nx 32.5 + D > 512   > 256 > 512   > 256 > 512 1.5 × 10-7
       T > 512   128 > 512   64 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, G, Ci
32.5 - Am, Cf, Cfx, Co, Of, Nx 32.5 - D 512   > 256 > 512   > 256 > 512 0.6 × 10-7
       T 512   64 512   64 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, C, G, Ci
32.5, 4.7 + Am, Cf, Cfx, Co, Of, Nx,
C, G
32.5 + D > 512 512 > 256 > 512 > 64 > 256 > 512 1.2 × 10-7
       T > 512 512 128 512 > 64 128 > 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, G, Ci
51 + Am, Cf, Cfx, Co, Of, Nx 51 - D 512   > 128 512   128 512 0.5 × 10-7
       T 256   32 256   32 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ak, Ca, G, Ci
38 + Am, Cf, Cfx, Co, Of, Nx 38 + D > 512   > 256 > 512   > 256 > 512 0.8 × 10-7
       T > 512   64 > 512   64 > 512  
Am, Cf, Co, Nx, Ca, Ci 38 - Am, Cf, Cfx, Co, Of, Nx 38 - D 512   128 > 512   128 512 0.5 × 10-7
       T 256   64 256   64 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
C, Ca, G, Ci
32.5, 6.5 + Am, Cf, Cfx, Co, Of, Nx 32.5, 6.5 + D 512   128 > 512   128 > 512 0.3 × 10-7
       T 512   64 > 512   64 > 512  
Am, Cf, Ce, Cfx, Co, Of, Nx,
Ca, Ci
32.5 + Am, Cf, Cfx, Co, Of, Nx 32.5 + D > 512   128 > 512   128 > 512 1.2 × 10-7
       T > 512   64 > 512   64 512  
  1. aConjugation frequency is the number of transconjugants per donor cell
  2. bESBL = extended-spectrum β-lactamase
  3. cMIC = minimum inhibitory concentration of antibiotic at which visible growth of isolates were inhibited
  4. Am-amoxycillin, Ce-cefotaxime, Cfx-cefixime, Cf-ciprofloxacin, Co-cotrimoxazole, Nf-nitrofurantoin, Nx-norfloxacin, Of-ofloxacin, Ak-amikacin, C-chloramphenicol, Ca-ceftazidime, Ci-ceftriaxone, G-gentamycin, D-donor, T-transconjugant