Skip to main content

Table 6 Biomarkers: Full Analysis Set

From: Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters

Biomarker Coll 2-1 (nM) n = 21 Coll 2-1 NO2 (nM) n = 21 CS-846 (ng/mL) n = 20 CP II (ng/mL) n = 21 IL-6 (pg/mL) n = 18
   mean ± SD    
V2 (baseline) 127 ± 62 0.44 ± 0.29 92 ± 24 1040 ± 518 5825 ± 21720
V6 (D84) 116 ± 37 0.38 ± 0.18 93 ± 21 1000 ± 646 162 ± 405
Change -11 ± 78 -0.06 ± 0.41 1 ± 17 -41 ± 865 -5663 ± 21769
  correlation coefficients (biomarkers change vs pain change)
Pearson -0.395 -0.412 -0.021 -0.469 -0.086
  p = 0.0766 p = 0.0637 p = 0.9296 p = 0.0319 p = 0.7354
Spearman -0.274 -0.262 0.026 -0.319 0.151
  p = 0.2287 p = 0.2512 p = 0.9122 p = 0.1584 p = 0.5500
  1. mL = milliliter; n = number of patients; ng = nanogram; nM = nanomolar; pg = picogram; SD = standard deviation.
  2. Note: Only patients with both a baseline value and a time point value are summarized at Visit 6; Correlation coefficients between the absolute change of each biomarker and the absolute change of pain from V2 and V6.