Intra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters

Table 6 Biomarkers: Full Analysis Set

Biomarker	Coll 2-1 (nM) n = 21	Coll 2-1 NO2 (nM) n = 21	CS-846 (ng/mL) n = 20	CP II (ng/mL) n = 21	IL-6 (pg/mL) n = 18
		mean ± SD
V2 (baseline)	127 ± 62	0.44 ± 0.29	92 ± 24	1040 ± 518	5825 ± 21720
V6 (D84)	116 ± 37	0.38 ± 0.18	93 ± 21	1000 ± 646	162 ± 405
Change	-11 ± 78	-0.06 ± 0.41	1 ± 17	-41 ± 865	-5663 ± 21769
	correlation coefficients (biomarkers change vs pain change)
Pearson	-0.395	-0.412	-0.021	-0.469	-0.086
	p = 0.0766	p = 0.0637	p = 0.9296	p = 0.0319	p = 0.7354
Spearman	-0.274	-0.262	0.026	-0.319	0.151
	p = 0.2287	p = 0.2512	p = 0.9122	p = 0.1584	p = 0.5500

mL = milliliter; n = number of patients; ng = nanogram; nM = nanomolar; pg = picogram; SD = standard deviation.
Note: Only patients with both a baseline value and a time point value are summarized at Visit 6; Correlation coefficients between the absolute change of each biomarker and the absolute change of pain from V2 and V6.

ISSN: 1756-0500