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Table 2 Overall breast cancer risk in relation to selected SNPs

From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer

SNP Rs number (Gene) Case/control N Breast cancer risk Crude OR (CI 95%) Breast cancer risk Adjusted OR* (CI 95%) Breast cancer risk Adjusted OR** (CI 95%)
rs2981582 (FGFR2)     
CC 233/561 1.00 1.00 1.00
CT 356/653 1.31 (1.08-1.60) 1.31 (1.07-1.60) 1.31 (1.07-1.61)
TT 124/185 1.61 (1.23-2.12) 1.62 (1.23-2.13) 1.63 (1.23-2.16)
Per allele   1.28 (1.12-1.46) 1.28 (1.12-1.46) 1.28 (1.12-1.47)
rs1045485 (CASP8)     
CC 185/374 1.00 1.00 1.00
CG 42/86 0.99 (0.66-1.49) 0.98 (0.65-1.48) 1.04 (0.69-1.58)
GG 8/10 1.62 (0.63-4.17) 1.61 (0.63-4.16) 1.73 (0.66-4.54)
Per allele   1.10 (0.79-1.51) 1.10 (0.80-1.54) 1.10 (0.79-1.54)
rs3803662 (TNRC9)     
CC 353/780 1.00 1.00 1.00
CT 278/512 1.20 (0.99-1.46) 1.20 (0.99-1.46) 1.19 (0.98-1.45)
TT 64/95 1.49 (1.06-2.09) 1.49 (1.06-2.10) 1.47 (1.04-2.08)
Per allele   1.21 (1.05-1.40) 1.21 (1.05-1.40) 1.20 (1.04-1.39)
rs8051542 (TNRC9)     
CC 192/443 1.00 1.00 1.00
CT 338/637 1.22 (0.99-1.52) 1.23 (0.99-1.52) 1.20 (0.97-1.50)
TT 149/272 1.26 (0.97-1.64) 1.27 (0.97-1.64) 1.24 (0.95-1.62)
Per allele   1.13 (1.00-1.29) 1.13 (1.00-1.29) 1.12 (0.99-1.28)
rs12443621 (TNRC9)     
AA 195/451 1.00 1.00 1.00
AG 338/657 1.19 (0.96-1.47) 1.19 (0.96-1.47) 1.20 (0.97-1.49)
GG 165/275 1.39 (1.07-1.79) 1.39 (1.08-1.79) 1.42 (1.09-1.84)
Per allele   1.18 (1.04-1.34) 1.18 (1.04-1.34) 1.19 (1.04-1.35)
rs889312 (MAP3K1)     
AA 322/737 1.00 1.00 1.00
AC 301/530 1.30 (1.07-1.58) 1.30 (1.07-1.58) 1.26 (1.03-1.53)
CC 66/118 1.28 (0.92-1.78) 1.28 (0.92-1.78) 1.29 (0.92-1.80)
Per allele   1.19 (1.04-1.37) 1.19 (1.04-1.37) 1.18 (1.02-1.36)
rs3817198 (LSP1)     
TT 311/668 1.00 1.00 1.00
CT 282/555 1.09 (0.90-1.33) 1.09 (0.90-1.33) 1.06 (0.87-1.30)
CC 76/107 1.53 (1.10-2.11) 1.53 (1.11-2.11) 1.50 (1.08-2.09)
Per allele   1.18 (1.02-1.36) 1.18 (1.02-1.36) 1.17 (1.10-1.35)
rs2107425 (H19)     
CC 361/637 1.00 1.00 1.00
CT 250/573 0.77 (0.63-0.94) 0.77 (0.63-0.94) 0.78 (0.64-0.95)
TT 68/145 0.83 (0.60-1.14) 0.83 (0.60-1.14) 0.83 (0.60-1.14)
Per allele   0.86 (0.74-0.99) 0.86 (0.74-0.99) 0.86 (0.75-0.99)
rs13281615 (8q24)     
AA 245/533 1.00 1.00 1.00
AG 332/633 1.14 (0.93-1.40) 1.14 (0.93-1.40) 1.14 (0.93-1.40)
GG 117/204 1.25 (0.95-1.64) 1.25 (0.95-1.64) 1.25 (0.95-1.64)
Per allele   1.12 (0.98-1.28) 1.12 (0.98-1.28) 1.15 (1.00-1.31)
rs981782 (5p12)     
TT 182/335 1.00 1.00 1.00
TG 352/685 0.95 (0.76-1.18) 0.95 (0.76-1.18) 0.91 (0.72-1.14)
GG 125/296 0.78 (0.59-1.03) 0.78 (0.59-1.03) 0.74 (0.56-0.98)
Per allele   0.89 (0.77-1.02) 0.89 (0.77-1.02) 0.87 (0.75-1.00)
rs30099 (5q)     
CC 584/1139 1.00 1.00 1.00
CT 113/248 0.89 (0.70-1.13) 0.89 (0.70-1.14) 0.90 (0.71-1.16)
TT 11/12 1.79 (0.78-4.08) 1.79 (0.78-4.10) 1.79 (0.77-4.18)
Per allele   0.98 (0.79-1.21) 0.98 (0.79-1.22) 0.99 (0.80-1.24)
rs4666451 (2p)     
GG 272/554 1.00 1.00 1.00
GA 299/574 1.06 (0.87-1.30) 1.06 (0.87-1.30) 1.08 (0.88-1.32)
AA 105/204 1.05 (0.80-1.38) 1.05 (0.79-1.38) 1.06 (0.80-1.40)
Per allele   1.03 (0.91-1.18) 1.03 (0.91-1.18) 1.04 (0.91-1.19)
rs13387042 (2q35)     
AA 192/335 1.00 1.00 1.00
AG 330/657 1.08 (0.86-1.36) 1.08 (0.86-1.35) 1.08 (0.86-1.37)
GG 163/350 1.23 (0.95-1.59) 1.23 (0.95-1.59) 1.24 (0.96-1.62)
Per allele   0.90 (0.79-1.03) 0.90 (0.79-1.03) 0.90 (0.79-1.02)
rs7766585 (ESR1)     
CC 518/1031 1.00 1.00 1.00
CT 172/348 0.98 (0.80-1.22) 0.98 (0.80-1.22) 0.98 (0.79-1.21)
TT 17/26 1.30 (0.70-2.42) 1.30 (0.70-2.42) 1.42 (0.76-2.67)
Per allele   1.03 (0.86-1.23) 1.03 (0.86-1.23) 1.03 (0.86-1.24)
  1. * Adjusted for matching variables (age and year of inclusion in study).
  2. ** Adjusted for matching variables (age and year of inclusion in study), and for selected confounders (socioeconomic status and exposure to HRT).