Table 4 Breast cancer risk in relation to selected SNPs with regard to age at first child-birth
From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer
Rs nr (Gene) | p-value inter-action | Case/ control N | Age < 25 years OR* (CI 95%) | Case/ control N | Age > 25 years OR* (CI 95%) |
|---|---|---|---|---|---|
rs2981582 (FGFR2) | 0.47 | ||||
CC | 110/291 | 1.00 | 90/202 | 1.00 | |
CT | 191/352 | 1.49 (1.20-1.99) | 119/219 | 1.18 (0.84-1.66) | |
TT | 60/95 | 1.68 (1.13-2.51) | 44/71 | 1.38 (0.87-2.20) | |
Per allele | 1.33 (1.10-1.61) | 1.17 (0.94-1.47) | |||
rs1045485 (CASP8) | 0.26 | ||||
CC | 104/192 | 1.00 | 58/126 | 1.00 | |
CG | 21/41 | 0.99 (0.55-1.80) | 14/30 | 1.14 (0.55-2.34) | |
GG | 3/7 | 0.88 (0.22-3.60) | 5/3 | 3.21 (0.71-14.61) | |
Per allele | 0.93 (0.58-1.49) | 1.38 (0.79-2.42) | |||
rs3803662 (TNRC9) | 0.91 | ||||
CC | 185/419 | 1.00 | 126/275 | 1.00 | |
CT | 143/257 | 1.25 (0.95-1.37) | 95/188 | 1.08 (0.78-1.51) | |
TT | 31/53 | 1.32 (0.81-2.16) | 23/29 | 1.72 (0.94-3.12) | |
Per allele | 1.19 (0.97-1.46) | 1.21 (0.94-1.55) | |||
rs8051542 (TNRC9) | 0.48 | ||||
CC | 112/256 | 1.00 | 65/143 | 1.00 | |
CT | 166/313 | 1.23 (0.91-1.65) | 123/244 | 1.06 (0.73-1.53) | |
TT | 68/149 | 1.01 (0.70-1.46) | 52/85 | 1.36 (0.85-2.16) | |
Per allele | 1.03 (0.86-1.23) | 1.16 (0.92-1.46) | |||
rs12443621 (TNRC9) | 0.82 | ||||
AA | 104/269 | 1.00 | 66/146 | 1.00 | |
AG | 169/312 | 1.48 (1.10-2.01) | 126/252 | 1.07 (0.74-1.55) | |
GG | 79/146 | 1.45 (1.01-2.08) | 56/91 | 1.39 (0.88-2.18) | |
Per allele | 1.22 (1.02-1.46) | 1.17 (0.93-1.46) | |||
rs889312 (MAP3K1) | 0.65 | ||||
AA | 153/371 | 1.00 | 120/282 | 1.00 | |
AC | 161/288 | 1.30 (0.99-1.71) | 100/172 | 1.33 (0.95-1.86) | |
CC | 37/68 | 1.38 (0.88-2.16) | 24/35 | 1.61 (0.91-2.86) | |
Per allele | 1.21 (1.00-1.48) | 1.30 (1.02-1.65) | |||
rs3817198 (LSP1) | 0.17 | ||||
TT | 160/359 | 1.00 | 111/232 | 1.00 | |
CT | 139/287 | 1.05 (0.79-1.39) | 100/195 | 1.04 (0.74-1.46) | |
CC | 44/50 | 2.00 (1.27-3.14) | 24/49 | 1.00 (0.58-1.73) | |
Per allele | 1.27 (1.04-1.55) | 1.02 (0.80-1.30) | |||
rs2107425 (H19) | 0.09 | ||||
CC | 191/329 | 1.00 | 120/240 | 1.00 | |
CT | 120/304 | 0.69 (0.52-0.91) | 93/194 | 0.99 (0.71-1.39) | |
TT | 35/78 | 0.78 (0.50-1.22) | 29/49 | 1.19 (0.71-2.00) | |
Per allele | 0.81 (0.66-0.99) | 1.06 (0.83-1.33) | |||
rs13281615 (8q24) | 0.80 | ||||
AA | 124/290 | 1.00 | 87/175 | 1.00 | |
AG | 172/323 | 1.27 (0.95-1.69) | 118/234 | 1.04 (0.74-1.48) | |
GG | 54/107 | 1.25 (0.84-1.86) | 45/76 | 1.27 (0.80-2.01) | |
Per allele | 1.15 (0.95-1.83) | 1.11 (0.89-1.39) | |||
rs981782 (5p12) | 0.38 | ||||
TT | 88/173 | 1.00 | 74/117 | 1.00 | |
TG | 185/351 | 0.96 (0.70-1.32) | 118/243 | 0.73 (0.50-1.06) | |
GG | 67/169 | 0.71 (0.48-1.05) | 40/104 | 0.60 (0.37-0.96) | |
Per allele | 0.85 (0.70-1.03) | 0.77 (0.61-0.98 | |||
rs30099 (5q) | 0.31 | ||||
CC | 299/621 | 1.00 | 206/393 | 1.00 | |
CT | 54/108 | 1.02 (0.71-1.46) | 43/97 | 0.83 (0.55-1.25) | |
TT | 6/6 | 2.47 (0.77-7.91) | 3/5 | 0.76 (0.16-3.62) | |
Per allele | 1.14 (0.83-1.56) | 0.85 (0.59-1.23) | |||
rs4666451 (2p) | 0.24 | ||||
GG | 131/301 | 1.00 | 106/192 | 1.00 | |
GA | 159/295 | 1.23 (0.92-1.64) | 97/207 | 0.89 (0.63-1.26) | |
AA | 53/109 | 1.11 (0.75-1.65) | 35/71 | 0.90 (0.56-1.45) | |
Per allele | 1.09 (0.91-1.31) | 0.93 (0.74-1.17) | |||
rs13387042 (2q35) | 0.89 | ||||
AA | 95/168 | 1.00 | 69/124 | 1.00 | |
AG | 170/348 | 0.86 (0.63-1.19) | 117/232 | 0.89 (0.61-1.30) | |
GG | 84/186 | 0.80 (0.55-1.15) | 56/121 | 0.84 (0.54-1.31) | |
Per allele | 0.89 (0.74-1.07) | 0.92 (0.74-1.14) | |||
rs7766585 (ESR1) | 0.60 | ||||
CC | 249/525 | 1.00 | 194/382 | 1.00 | |
CT | 99/199 | 1.07 (0.80-1.43) | 51/110 | 0.88 (0.60-1.29) | |
TT | 11/13 | 2.06 (0.89-4.75) | 6/7 | 1.68 (0.55-5.19) | |
Per allele | 1.07 (0.98-1.18) | 0.98 (0.90-1.08) |