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Table 4 Breast cancer risk in relation to selected SNPs with regard to age at first child-birth

From: Genetic predisposition, parity, age at first childbirth and risk for breast cancer

Rs nr (Gene) p-value inter-action Case/ control N Age <  25 years OR* (CI 95%) Case/ control N Age > 25 years OR* (CI 95%)
rs2981582 (FGFR2) 0.47     
CC   110/291 1.00 90/202 1.00
CT   191/352 1.49 (1.20-1.99) 119/219 1.18 (0.84-1.66)
TT   60/95 1.68 (1.13-2.51) 44/71 1.38 (0.87-2.20)
Per allele    1.33 (1.10-1.61)   1.17 (0.94-1.47)
rs1045485 (CASP8) 0.26     
CC   104/192 1.00 58/126 1.00
CG   21/41 0.99 (0.55-1.80) 14/30 1.14 (0.55-2.34)
GG   3/7 0.88 (0.22-3.60) 5/3 3.21 (0.71-14.61)
Per allele    0.93 (0.58-1.49)   1.38 (0.79-2.42)
rs3803662 (TNRC9) 0.91     
CC   185/419 1.00 126/275 1.00
CT   143/257 1.25 (0.95-1.37) 95/188 1.08 (0.78-1.51)
TT   31/53 1.32 (0.81-2.16) 23/29 1.72 (0.94-3.12)
Per allele    1.19 (0.97-1.46)   1.21 (0.94-1.55)
rs8051542 (TNRC9) 0.48     
CC   112/256 1.00 65/143 1.00
CT   166/313 1.23 (0.91-1.65) 123/244 1.06 (0.73-1.53)
TT   68/149 1.01 (0.70-1.46) 52/85 1.36 (0.85-2.16)
Per allele    1.03 (0.86-1.23)   1.16 (0.92-1.46)
rs12443621 (TNRC9) 0.82     
AA   104/269 1.00 66/146 1.00
AG   169/312 1.48 (1.10-2.01) 126/252 1.07 (0.74-1.55)
GG   79/146 1.45 (1.01-2.08) 56/91 1.39 (0.88-2.18)
Per allele    1.22 (1.02-1.46)   1.17 (0.93-1.46)
rs889312 (MAP3K1) 0.65     
AA   153/371 1.00 120/282 1.00
AC   161/288 1.30 (0.99-1.71) 100/172 1.33 (0.95-1.86)
CC   37/68 1.38 (0.88-2.16) 24/35 1.61 (0.91-2.86)
Per allele    1.21 (1.00-1.48)   1.30 (1.02-1.65)
rs3817198 (LSP1) 0.17     
TT   160/359 1.00 111/232 1.00
CT   139/287 1.05 (0.79-1.39) 100/195 1.04 (0.74-1.46)
CC   44/50 2.00 (1.27-3.14) 24/49 1.00 (0.58-1.73)
Per allele    1.27 (1.04-1.55)   1.02 (0.80-1.30)
rs2107425 (H19) 0.09     
CC   191/329 1.00 120/240 1.00
CT   120/304 0.69 (0.52-0.91) 93/194 0.99 (0.71-1.39)
TT   35/78 0.78 (0.50-1.22) 29/49 1.19 (0.71-2.00)
Per allele    0.81 (0.66-0.99)   1.06 (0.83-1.33)
rs13281615 (8q24) 0.80     
AA   124/290 1.00 87/175 1.00
AG   172/323 1.27 (0.95-1.69) 118/234 1.04 (0.74-1.48)
GG   54/107 1.25 (0.84-1.86) 45/76 1.27 (0.80-2.01)
Per allele    1.15 (0.95-1.83)   1.11 (0.89-1.39)
rs981782 (5p12) 0.38     
TT   88/173 1.00 74/117 1.00
TG   185/351 0.96 (0.70-1.32) 118/243 0.73 (0.50-1.06)
GG   67/169 0.71 (0.48-1.05) 40/104 0.60 (0.37-0.96)
Per allele    0.85 (0.70-1.03)   0.77 (0.61-0.98
rs30099 (5q) 0.31     
CC   299/621 1.00 206/393 1.00
CT   54/108 1.02 (0.71-1.46) 43/97 0.83 (0.55-1.25)
TT   6/6 2.47 (0.77-7.91) 3/5 0.76 (0.16-3.62)
Per allele    1.14 (0.83-1.56)   0.85 (0.59-1.23)
rs4666451 (2p) 0.24     
GG   131/301 1.00 106/192 1.00
GA   159/295 1.23 (0.92-1.64) 97/207 0.89 (0.63-1.26)
AA   53/109 1.11 (0.75-1.65) 35/71 0.90 (0.56-1.45)
Per allele    1.09 (0.91-1.31)   0.93 (0.74-1.17)
rs13387042 (2q35) 0.89     
AA   95/168 1.00 69/124 1.00
AG   170/348 0.86 (0.63-1.19) 117/232 0.89 (0.61-1.30)
GG   84/186 0.80 (0.55-1.15) 56/121 0.84 (0.54-1.31)
Per allele    0.89 (0.74-1.07)   0.92 (0.74-1.14)
rs7766585 (ESR1) 0.60     
CC   249/525 1.00 194/382 1.00
CT   99/199 1.07 (0.80-1.43) 51/110 0.88 (0.60-1.29)
TT   11/13 2.06 (0.89-4.75) 6/7 1.68 (0.55-5.19)
Per allele    1.07 (0.98-1.18)   0.98 (0.90-1.08)
  1. *Adjusted for: age, year of inclusion in study, socioeconomic status and exposure to HRT.