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Table 2 Hemodynamic variables before and during clonidine treatment. Median (range) values at supine rest (baseline) and the response (Δ) to 20 deg. head-up tilt-test

From: Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial

 

Baseline

Δ (Tilt - Baseline)

 

Before clonidine

During clonidine

Before clonidine

During clonidine

HR (beats/min)

69.5

65.4

1.7

1.4

 

(63.1-107.1)

(59.5-88.0)

(−0.1-4.4)

(−1.0-6.7)

SBP (mm Hg)

101.8

101.2

0.9

−1.5

 

(91.0-104.9)

(96.2-107.4)

(−10.4-5.1)

(−5.7-9.0)

MBP (mm Hg)

76.1

74.0

2.5

−2.0

 

(65.4-76.1)

(68.9-80.8)

(−9.5-5.6)

(−3.7-2.0)

DBP (mm Hg)

62.1

59.1

4.0

−2.8

 

(53.5-70.6)

(57.4-64.0)

(−9.4-4.6)

(−3.2-0.8)

SI (ml/m2)

50.4

42.7

−4.8

−3.4

 

(32.1-62.2)

(34.6-78.2)

(−6.0--2.8)

(−8.2--1.3)

CI (l/min/m2)

3.4

3.0

−0.3

−0.1

 

(3.3-3.9)

(2.5-4.7)

(−0.3-0.0)

(−0.4-0.0)

TPRI (mm Hg/l/min/m2)

9.0

9.0

0.8

0.3

 

(6.3-9.6)

(5.2-13.2)

(−0.3-1.6)

(−0.1-1.1)

LF/HF

0.56

0.57

0.58

0.36

 

(0.30-0.93)

(0.38-0.64)

(−0.05-0.82)

(−0.01-0.68)

  1. HR=heart rate; SBP=systolic blood pressure; MBP=mean arterial blood pressure; DBP=diastolic blood pressure; SI=stroke index; CI=cardiac index; TPRI=total peripheral resistance index; LF/HF=low-frequency:high-frequency heart rate variability ratio.