Skip to main content

Table 2 Genotype frequencies of the NR1H4 variants in the study population and the genotype association analysis

From: Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease

SNP rs3863377 (G→ A)

 

WT [GG]

Het [GA]

Hom [AA] (%)

P

P’

OR

CI

χ 2

non-IBD

506 (94.4)

28 (5.2)

2 (0.4)

    

0.14

IBD

438 (97.8)

10 (2.2)

0

0.009** †

0.022*

0.39

0.19-0.80

0.01

CD

271 (97.8)

6 (2.2)

0

0.030* †

0.031*

0.37

0.15-0.191

0.01

UC

167 (97.7)

4 (2.3)

0

0.100 †

0.066

0.40

0.14-1.16

0.01

SNP rs56163822 (−1G → T)

 

WT [GG]

Het [GT]

Horn [TT] (%)

P

P’

OR

CI

χ 2

non-IBD

560 (96.6)

20 (3.4)

0

    

0.04

IBD

505 (93.9)

33 (6.1)

1 (0.09)

0.035*

0.451

1.83

1.04-3.23

0.00

CD

319 (94.4)

19 (5.6)

1 (0.09)

0.115

0.846

1.67

0.88-3. 17

0.00

UC

186 (93.0)

14 (7.0)

0

0.034*

0.154

2.11

1.04-4.26

0.13

SNP rs7138843 (A → T)

 

WT [AA]

Het [AT]

Horn [TT] (%)

P

P’

OR

CI

χ 2

non-IBD

495 (96.7)

17 (3.3)

0

    

0.03

IBD

417 (95.2)

21 (4.8)

0

0.248

0.772

147

0.76-2.82

0.06

CD

261 (96.0)

11 (4.0)

0

0.369 †

0.612

1.23

0.57-2.66

0.04

UC

156 (94.0)

10 (6.0)

0

0.097 †

0.981

1.87

0.84-4.16

0.10

SNP rs10860603 (G → A)

 

WT [GG]

Het [GA]

Horn [AA] (%)

P

P’

OR

CI

χ 2

non-IBD

424 (72.8)

143 (24.6)

15 (2.6)

    

049

IBD

407 (75.8)

121 (22.5)

9 (1.7)

0.261

0.384

0.86

0.66-1.12

0.00

CD

254 (75.4)

76 (22.5)

7 (2.1)

0.403

0.611

0.88

0.65-1.19

0.22

tiC

153 (76.5)

45 (22.5)

2 (1.0)

0.312

0.521

0.82

0.57-1.19

0.43

SNP rs35724 (G→ C)

 

WT [GG]

Het [GC]

Horn [CC] (%)

P

P’

OR

CI

χ 2

non-IBD

217 (37.3)

264 (454)

101 (17.3)

    

1.78

IBD

177 (32.9)

251 (46.7

110 (20.4)

0.125

0.209

1.213

0.95-1.55

1.47

CD

111 (32.8)

155 (45.9)

72 (21.3)

0.175

0.279

1.216

0.92-1.61

1.68

UC

66 (33.0)

96 (48.0)

38 (19.0)

0.277

0.233

1.207

0.86-1.69

0.09