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Table 2 Genotype frequencies of the NR1H4 variants in the study population and the genotype association analysis

From: Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease

SNP rs3863377 (G→ A)
  WT [GG] Het [GA] Hom [AA] (%) P P’ OR CI χ 2
non-IBD 506 (94.4) 28 (5.2) 2 (0.4)      0.14
IBD 438 (97.8) 10 (2.2) 0 0.009** † 0.022* 0.39 0.19-0.80 0.01
CD 271 (97.8) 6 (2.2) 0 0.030* † 0.031* 0.37 0.15-0.191 0.01
UC 167 (97.7) 4 (2.3) 0 0.100 † 0.066 0.40 0.14-1.16 0.01
SNP rs56163822 (−1G → T)
  WT [GG] Het [GT] Horn [TT] (%) P P’ OR CI χ 2
non-IBD 560 (96.6) 20 (3.4) 0      0.04
IBD 505 (93.9) 33 (6.1) 1 (0.09) 0.035* 0.451 1.83 1.04-3.23 0.00
CD 319 (94.4) 19 (5.6) 1 (0.09) 0.115 0.846 1.67 0.88-3. 17 0.00
UC 186 (93.0) 14 (7.0) 0 0.034* 0.154 2.11 1.04-4.26 0.13
SNP rs7138843 (A → T)
  WT [AA] Het [AT] Horn [TT] (%) P P’ OR CI χ 2
non-IBD 495 (96.7) 17 (3.3) 0      0.03
IBD 417 (95.2) 21 (4.8) 0 0.248 0.772 147 0.76-2.82 0.06
CD 261 (96.0) 11 (4.0) 0 0.369 † 0.612 1.23 0.57-2.66 0.04
UC 156 (94.0) 10 (6.0) 0 0.097 † 0.981 1.87 0.84-4.16 0.10
SNP rs10860603 (G → A)
  WT [GG] Het [GA] Horn [AA] (%) P P’ OR CI χ 2
non-IBD 424 (72.8) 143 (24.6) 15 (2.6)      049
IBD 407 (75.8) 121 (22.5) 9 (1.7) 0.261 0.384 0.86 0.66-1.12 0.00
CD 254 (75.4) 76 (22.5) 7 (2.1) 0.403 0.611 0.88 0.65-1.19 0.22
tiC 153 (76.5) 45 (22.5) 2 (1.0) 0.312 0.521 0.82 0.57-1.19 0.43
SNP rs35724 (G→ C)
  WT [GG] Het [GC] Horn [CC] (%) P P’ OR CI χ 2
non-IBD 217 (37.3) 264 (454) 101 (17.3)      1.78
IBD 177 (32.9) 251 (46.7 110 (20.4) 0.125 0.209 1.213 0.95-1.55 1.47
CD 111 (32.8) 155 (45.9) 72 (21.3) 0.175 0.279 1.216 0.92-1.61 1.68
UC 66 (33.0) 96 (48.0) 38 (19.0) 0.277 0.233 1.207 0.86-1.69 0.09