Skip to main content

Table 1 Summary of LOD scores for the four parameter models

From: MLEP: an R package for exploring the maximum likelihood estimates of penetrance parameters

Model Recombination fraction(θ)
0 0.05 0.1 0.15 0.2 0.25 0.3 0.35 0.4 0.45
True 4.071 3.831 3.535 3.201 2.835 2.438 2.011 1.553 1.066 0.549
Dominant -0.158 3.296 3.394 3.240 2.965 2.609 2.189 1.714 1.189 0.617
MLE (with γ constraint) 3.992 3.797 3.520 3.198 2.838 2.444 2.017 1.559 1.069 0.550
MLE (unconstrained) 0.781 0.792 0.710 0.603 0.487 0.370 0.260 0.167 0.095 0.041