Table 1 Summary of LOD scores for the four parameter models
From: MLEP: an R package for exploring the maximum likelihood estimates of penetrance parameters
Model | Recombination fraction(θ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
0 | 0.05 | 0.1 | 0.15 | 0.2 | 0.25 | 0.3 | 0.35 | 0.4 | 0.45 | |
True | 4.071 | 3.831 | 3.535 | 3.201 | 2.835 | 2.438 | 2.011 | 1.553 | 1.066 | 0.549 |
Dominant | -0.158 | 3.296 | 3.394 | 3.240 | 2.965 | 2.609 | 2.189 | 1.714 | 1.189 | 0.617 |
MLE (with γ constraint) | 3.992 | 3.797 | 3.520 | 3.198 | 2.838 | 2.444 | 2.017 | 1.559 | 1.069 | 0.550 |
MLE (unconstrained) | 0.781 | 0.792 | 0.710 | 0.603 | 0.487 | 0.370 | 0.260 | 0.167 | 0.095 | 0.041 |