Table 1 Summary sensitivity and specificity based on bivariate model with no covariates
Data | Median Sensitivity (95% CI)[95% PI] | Median specificity (95% CI)[95% PI] | Heterogeneity SD on logit scale (sens) | Heterogeneity SD on logit scale (spec) | |
|---|---|---|---|---|---|
Primary analysis (n = 10,587, 90 studies) | 96.6 (95.2, 97.7) [64.4, 99.8] | 98.9 (98.1, 99.4) [75.8, 100.0) | 1.4 | 1.7 | |
Breakdown by trimester (n = 4,467, 35 studies) | First trimester (n = 2,244, 26 studies) | 95.0 (92.2, 97.3) [71.7, 99.4] | 98.8 (97.0, 99.7) [64.0, 100.0) | 1.0 | 1.7 |
Second trimester (n = 1,662, 15 studies) | 98.2 (95.2, 99.6) [64.9, 100.0] | 99.5 (98.2, 100.0) [77.0,100] | 1.6 | 1.6 | |
Third trimester (n = 561, 9 studies) | 96.6 (86.6, 99.7) [28.0, 100.0] | 99.0 (95.4, 99.9) [70.6, 100.0] | 1.8 | 1.3 | |