Table 2 Genotype and allele frequencies of cytokine genotypes in patients with acute hepatitis C with viral clearance and patients with chronic hepatitis C
Gene polymorphism | Genotype and allele | Acute hepatitis C with viral clearance | Chronic hepatitis C | (p) |
|---|---|---|---|---|
IL-10 | n = 17 | n = 161 | ||
(−1082) | A/A | 07 (41.2%) | 106 (65.8%) | |
A/G | 03 (17.6%) | 45 (28%) | ||
G/G | 07 (41.2%) | 10 (6.2%) | 0.001* | |
A | 17 (50%) | 257 (79.8%) | ||
G | 17 (50%) | 65 (20.2%) | 0.001* | |
(−819) | C/C | 08 (47.1%) | 58 (36%) | |
C/T | 05 (29.4%) | 60 (37.3%) | ||
T/T | 04 (23.5%) | 43 (26.7%) | 0.504 | |
C | 21 (61.8%) | 176 (54.7%) | ||
T | 13 (38.2%) | 146 (45.3) | 0.101 | |
IL-4 | n = 18 | n = 147 | ||
(+33) | C/C | 13 (72.2%) | 54 (36.7%) | |
C/T | 04 (22.2%) | 53 (36.1%) | ||
T/T | 01 (5.6%) | 40 (27.2%) | 0.017* | |
C | 30 (73.4%) | 161 (54.8%) | ||
T | 06 (16.6%) | 133 (45.2%) | 0.004* | |
IFN-γ | n = 18 | n = 149 | ||
(+874) | T/T | 02 (11.1%) | 25 (16.4%) | |
T/A | 09 (50%) | 66 (44.3%) | ||
A/A | 07 (38.9%) | 58 (38.9%) | 0.804 | |
T | 13 (36.2%) | 116 (38.9%) | ||
A | 23 (63.8%) | 182 (61.1%) | 0.858 | |
TNF-α | n = 18 | n = 124 | ||
(−308) | G/G | 10 (61.9%) | 75 (59.5%) | |
G/A | 03 (14.3%) | 27 (22.3%) | ||
A/A | 05 (23.8%) | 22 (18.2%) | 0.580 | |
G | 23 (63.9%) | 177 (71.4%) | ||
A | 13 (36.1%) | 71 (28.6%) | 0.832 | |
(−238) | G/G | 16 (88.9%) | 114 (91.9%) | |
G/A | 02 (11.1%) | 10 (8.1%) | 0.560 | |
G | 34 (94.5%) | 238 (96%) | ||
A | 02 (5.5%) | 10 (4%) | 0.388 | |
IL-28B | n = 18 | n = 119 | ||
(rs12979860) | C/C | 16 (88.9%) | 36 (30.3%) | |
C/T | 00 (0.0%) | 61 (51.3%) | ||
T/T | 02 (11.1%) | 22 (18.5%) | <0.001* | |
C | 32 (88.9%) | 133 (55.9%) | ||
T | 04 (11.1%) | 105 (44.1%) | <0.001* | |
n = 18 | n = 133 | |||
(rs8099917) | T/T | 16 (88.9%) | 66 (49.6%) | |
T/G | 00 (0.0%) | 25 (18.8%) | ||
G/G | 02 (11.1%) | 42 (31.6%) | 0.002* | |
T | 32 (88.9%) | 157 (59%) | ||
G | 04 (11.1%) | 109 (41%) | <0.001* |