The clinical course of alcoholic cirrhosis: effects of hepatic metabolic capacity, alcohol consumption, and hyponatremia – a historical cohort study

Table 2 Effects of galactose elimination capacity, alcohol consumption, and plasma sodium concentration on the clinical course of alcoholic cirrhosis

	Hepatic encephalopathy		Ascites		Variceal bleeding		Death
	All patients at risk	Patients at risk + with GEC test	All patients at risk	Patients at risk + with GEC test	All patients at risk	Patients at risk + with GEC test	All patients at risk	Patients at risk + with GEC test
	N = 417	N = 237	N = 164	N = 56	N = 410	N = 231	N = 466	N = 266
GEC, per 0.1 mmol/min loss		1.21 (1.11-1.31)		1.04 (0.84-1.30)		1.01 (0.95-1.08)		1.04 (0.98-1.10)
Alcohol consumption	0.93 (0.51-1.70)	0.82 (0.45-1.50)	1.95 (1.16-3.26)	3.18 (1.19-8.47)	2.01 (1.28-3.14)	2.78 (1.59-4.87)	2.20 (1.68-2.88)	2.45 (1.63-3.66)
Plasma sodium, per mmol/L loss	1.14 (1.10-1.19)	1.14 (1.09-1.18)	1.12 (1.05-1.20)	1.16 (1.06-1.28)	1.08 (1.05-1.11)	1.07 (1.04-1.10)	1.13 (1.11-1.15)	1.14 (1.11-1.18)

Effects are expressed as hazard ratios controlled for confounding by the two other patho-etiological measures, gender, age, and Charlson comorbidity index. Statistically significant associations are highlighted with bold font.

ISSN: 1756-0500