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Table 1 Hydrogen bonds between amino acid residues and NADPH for WT, S140A and S140T MabA proteins

From: Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)

  Hydrogen bond Hydrophobic contact
Protein Residues Atoms Distance (Å) Residues
 MtMabAWT Gly22 O → O3B 2.9 Pro183
Asn24 OD1 → O3B 2.9 Val217
Ile27 N → O2N 2.9  
  ND2 → O2X 3.0  
Arg47 NH2 → O1X 3.4  
  NE → O1X 2.90  
  N → O2X 3.1  
Asp61 OD1 → N6A 3.2  
Val62 N → N1A 3.0  
Gly90 N → O4B 3.2  
Asn88 O → O3D 3.2  
Ile138 O → O3D 3.1  
Gly139 N → O2D 3.3  
Tyr153 OH → O2D 3.0  
Ile186 N → O7N 3.0  
Lys157 NZ → O3D 3.1  
MtMabAS140A Gly22 O → O3B 2.9 Asp61
Asn24 OD1 → O3B 2.9 Pro183
Ile27 N → O2N 3.0 Val217
Val62 N → N1A 2.9  
Asn88 O → O3D 3.0  
Gly90 N → O4B 3.1  
Ile138 O → O3D 3.2  
Gly139 N → O2D 3.4  
Tyr153 OH → O2D 3.2  
Ile186 N → O7N 2.9  
MtMabAS140T Gly22 O → O3B 3.0 Asp61
Asn24 OD1 → O3B 3.0 Arg25
Ile27 N → O2N 3.1 Ala89
Val62 N → N1A 2.8 Pro183
Asn88 O → O3D 3.0 Val217
  OD1 → O3 3.3  
Gly90 N → O4B 3.1  
Ile138 O → O3D 3.4  
Gly139 O → O2D 3.4  
Tyr153 OH → O2D 3.0  
Ile186 N → O7N 2.9  
Tyr188 OG1 → N7N 2.8