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Table 2 Cross-sectional associations between high sensitive C-Reactive Protein (CRP), Interleukin 6 (IL- 6), Prostaglandin F 2 alpha (PGF 2 alpha), serum amyloid protein (SAA) and eGFR cyst and albumin creatinine ratio (ACR) at age 77: Multivariable regression

From: Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study

 

Cystatin C estimated glomerular filtration rate

lnAlbumin creatinine ratio (ACR)

 

total cohort (n = 647)

eGFR > 60 ml/min/1.73 m2 (n = 514)

total cohort (n = 647)

ACR < 3 mg/mmol (n = 522)

 

β-coefficient (95% CI)

β-coefficient (95% CI)

β-coefficient (95% CI)

β-coefficient (95% CI)

Model A

    

ln CRP (mg/L)

−0.23 (−0.30 to −0.15)***

−0.10 (−0.17 to −0.34)**

0.11 (0.03 to 0.19) **

0.07 (−0.04 to 0.06)

ln PGF2α (nmol/mmol)

−0.01 (−0.07 to 0.08)

−0.01(−0.08 to −0.05)

0.01 (−0.07 to 0.09)

0.05 (0.002 to 0.10) *

ln IL-6 (ng/L)

−0.28 (−0.35 to −0.20)***

−0.10 (−0.17 to −0.04) **

0.13 (0.06 to 0.21) **

0.01 (−0.04 to 0.05)

ln SAA (mg/L)

−0.15 (−0.22 to-0.07)***

−0.05 (−0.12 to 0.02)

0.14 (0.06 to 0.21) **

0.05 (0.002 to 0.10) *

Model B (DAG adjusted)

    

ln CRP (mg/L)

−0.19 (−0.26 to −0.11)***

−0.09 (−0.16 to −0.02) **

0.09 (0.01 to 0.16) *

−0.01 (−0.05 to 0.04)

ln PGF2α (nmol/mmol)

−0.01 (−0.07 to 0.08)

−0.02 (−0.09 to 0.04)

0.01 (−0.06 to 0.09)

0.03 (−0.01 to 0.08)

ln IL-6 (ng/L)

−0.23 (−0.30 to −0.15) ***

−0.09 (−0.16 to −0.02)*

0.11 (0.03 to 0.19) **

−0.01 (−0.05 to 0.04)

ln SAA (mg/L)

−0.13 (−0.21 to −0.06)**

−0.05 (−0.12 to 0.02)

0.12 (0.05 to 0.20) **

0.04 (−0.008 to 0.09)

Model C

    

ln CRP (mg/L)

−0.19 (−0.26 to −0.11)***

−0.09 (−0.16 to −0.02)**

0.08 (0.01 to 0.16) *

−0.01 (−0.06 to 0.04)

ln PGF2α (nmol/mmol)

−0.01 (−0.07 to 0.08)

−0.02 (−0.09 to 0.04)

−0.04 (−0.08 to 0.07)

0.03 (−0.02 to 0.08)

ln IL-6 (ng/L)

−0.23 (−0.30 to −0.15)***

−0.09 (−0.16 to −0.02)**

0.09 (0.01 to 0.16) *

−0.01 (−0.06 to 0.04)

ln SAA (mg/L)

−0.13 (−0.21 to −0.06)***

−0.05 (−0.12 to 0.02)

0.11 (0.04 to 0.19) **

0.04 (−0.01 to 0.09)

  1. Data are regression coefficients for a 1-SD higher ln C-reactive protein (CRP), ln interleukin 6 (IL- 6), ln prostaglandin F2 ln α (PGF2α),ln serum amyloid protein A (SAA). Model A was adjusted for age; model B was adjusted according to directed acyclic graphs (DAG): age, BMI, smoking, systolic and diastolic blood pressure, LDL, HDL, and triglyceride, statin treatment, ACE inhibitor-, ASA-, anti-inflammation-, and cortisone medication. Model C was adjusted for: age, BMI, smoking, systolic and diastolic blood pressure, hypertension treatment, LDL, HDL, and triglyceride, statin treatment, diabetes, ACE inhibitor-, ASA-, anti-inflammation-, and corticosteroid treatment, and CVD. * p < 0.05, **p < 0.01. *** p < 0.001.
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BMC Research Notes

ISSN: 1756-0500

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