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Table 2 Cross-sectional associations between high sensitive C-Reactive Protein (CRP), Interleukin 6 (IL- 6), Prostaglandin F 2 alpha (PGF 2 alpha), serum amyloid protein (SAA) and eGFR cyst and albumin creatinine ratio (ACR) at age 77: Multivariable regression

From: Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study

  Cystatin C estimated glomerular filtration rate lnAlbumin creatinine ratio (ACR)
  total cohort (n = 647) eGFR > 60 ml/min/1.73 m2 (n = 514) total cohort (n = 647) ACR < 3 mg/mmol (n = 522)
  β-coefficient (95% CI) β-coefficient (95% CI) β-coefficient (95% CI) β-coefficient (95% CI)
Model A     
ln CRP (mg/L) −0.23 (−0.30 to −0.15)*** −0.10 (−0.17 to −0.34)** 0.11 (0.03 to 0.19) ** 0.07 (−0.04 to 0.06)
ln PGF (nmol/mmol) −0.01 (−0.07 to 0.08) −0.01(−0.08 to −0.05) 0.01 (−0.07 to 0.09) 0.05 (0.002 to 0.10) *
ln IL-6 (ng/L) −0.28 (−0.35 to −0.20)*** −0.10 (−0.17 to −0.04) ** 0.13 (0.06 to 0.21) ** 0.01 (−0.04 to 0.05)
ln SAA (mg/L) −0.15 (−0.22 to-0.07)*** −0.05 (−0.12 to 0.02) 0.14 (0.06 to 0.21) ** 0.05 (0.002 to 0.10) *
Model B (DAG adjusted)     
ln CRP (mg/L) −0.19 (−0.26 to −0.11)*** −0.09 (−0.16 to −0.02) ** 0.09 (0.01 to 0.16) * −0.01 (−0.05 to 0.04)
ln PGF (nmol/mmol) −0.01 (−0.07 to 0.08) −0.02 (−0.09 to 0.04) 0.01 (−0.06 to 0.09) 0.03 (−0.01 to 0.08)
ln IL-6 (ng/L) −0.23 (−0.30 to −0.15) *** −0.09 (−0.16 to −0.02)* 0.11 (0.03 to 0.19) ** −0.01 (−0.05 to 0.04)
ln SAA (mg/L) −0.13 (−0.21 to −0.06)** −0.05 (−0.12 to 0.02) 0.12 (0.05 to 0.20) ** 0.04 (−0.008 to 0.09)
Model C     
ln CRP (mg/L) −0.19 (−0.26 to −0.11)*** −0.09 (−0.16 to −0.02)** 0.08 (0.01 to 0.16) * −0.01 (−0.06 to 0.04)
ln PGF (nmol/mmol) −0.01 (−0.07 to 0.08) −0.02 (−0.09 to 0.04) −0.04 (−0.08 to 0.07) 0.03 (−0.02 to 0.08)
ln IL-6 (ng/L) −0.23 (−0.30 to −0.15)*** −0.09 (−0.16 to −0.02)** 0.09 (0.01 to 0.16) * −0.01 (−0.06 to 0.04)
ln SAA (mg/L) −0.13 (−0.21 to −0.06)*** −0.05 (−0.12 to 0.02) 0.11 (0.04 to 0.19) ** 0.04 (−0.01 to 0.09)
  1. Data are regression coefficients for a 1-SD higher ln C-reactive protein (CRP), ln interleukin 6 (IL- 6), ln prostaglandin F2 ln α (PGF),ln serum amyloid protein A (SAA). Model A was adjusted for age; model B was adjusted according to directed acyclic graphs (DAG): age, BMI, smoking, systolic and diastolic blood pressure, LDL, HDL, and triglyceride, statin treatment, ACE inhibitor-, ASA-, anti-inflammation-, and cortisone medication. Model C was adjusted for: age, BMI, smoking, systolic and diastolic blood pressure, hypertension treatment, LDL, HDL, and triglyceride, statin treatment, diabetes, ACE inhibitor-, ASA-, anti-inflammation-, and corticosteroid treatment, and CVD. * p < 0.05, **p < 0.01. *** p < 0.001.
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