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Table 4 Association IVS4G > T mutation in TCF7L2 gene after genotypic groupings, distributed by genotype for the mutation in the CFTR gene delF508 with clinical variables in cystic fibrosis patients followed at the Pediatric Clinic at UNICAMP with the distribution by mutations in the CFTR gene

From: Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients

F508del Sex Male Female Chi-square p-value
-/- G/G 8 (53.3%) 7 (46.7%) 0.257 0.613
  G/T and T/T 15 (45.5%) 18 (54.5%)   
F508del/- G/G 13 (48.1%) 14 (51.9%) 0.931 0.335
  G/T and T/T 20 (60.6%) 13 (39.4%)   
F508del/F508del G/G 5 (41.7%) 7 (58.3%) 0.018 0.893
  G/T and T/T 11 (44%) 14 (54%)   
F508del Diabetes No Yes   
-/- G/G 12 (80%) 3 (20%) 0.01 0.919
  G/T and T/T 26 (81.3%) 6 (18.8%)   
F508del/- G/G 19 (70.4%) 8 (29.6%) 2.652 0.103
  G/T and T/T 28 (87.5%) 4 (12.5%)   
F508del/F508del G/G 8 (66.7%) 4 (33.3%) 1.437 0.231
  G/T and T/T 21 (84%) 4 (16%)   
F508del Meconium ileus No Yes   
-/- G/G 15 (100%) - 1.455 0.228
  G/T and T/T 30 (90.9%) 3 (9.1%)   
F508del/- G/G 22 (81.5%) 5 (18.5%) 0.067 0.795
  G/T and T/T 26 (78.8%) 7 (21.2%)   
F508del/F508del G/G 10 (83.3%) 2 (16.7%) 0.566 0.452
  G/T and T/T 18 (72%) 7 (28%)   
F508del Age ≤ 154 months > 154 months   
-/- G/G 4 (26.7%) 11 (73.3%) 0.032 0.857
  G/T and T/T 8 (24.2%) 25 (75.8%)   
F508del/- G/G 15 (55.6%) 12 (44.4%) 0.297 0.586
  G/T and T/T 16 (48.5%) 17 (51.5%)   
F508del/F508del G/G 9 (75%) 3 (25%) 1.009 0.315
  G/T and T/T 22 (88%) 3 (12%)   
  1. (-) absence of F508del mutation.