Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients

Table 4 Association IVS4G > T mutation in TCF7L2 gene after genotypic groupings, distributed by genotype for the mutation in the CFTR gene delF508 with clinical variables in cystic fibrosis patients followed at the Pediatric Clinic at UNICAMP with the distribution by mutations in the CFTR gene

F508del	Sex	Male	Female	Chi-square	p-value
-/-	G/G	8 (53.3%)	7 (46.7%)	0.257	0.613
	G/T and T/T	15 (45.5%)	18 (54.5%)
F508del/-	G/G	13 (48.1%)	14 (51.9%)	0.931	0.335
	G/T and T/T	20 (60.6%)	13 (39.4%)
F508del/F508del	G/G	5 (41.7%)	7 (58.3%)	0.018	0.893
	G/T and T/T	11 (44%)	14 (54%)
F508del	Diabetes	No	Yes
-/-	G/G	12 (80%)	3 (20%)	0.01	0.919
	G/T and T/T	26 (81.3%)	6 (18.8%)
F508del/-	G/G	19 (70.4%)	8 (29.6%)	2.652	0.103
	G/T and T/T	28 (87.5%)	4 (12.5%)
F508del/F508del	G/G	8 (66.7%)	4 (33.3%)	1.437	0.231
	G/T and T/T	21 (84%)	4 (16%)
F508del	Meconium ileus	No	Yes
-/-	G/G	15 (100%)	-	1.455	0.228
	G/T and T/T	30 (90.9%)	3 (9.1%)
F508del/-	G/G	22 (81.5%)	5 (18.5%)	0.067	0.795
	G/T and T/T	26 (78.8%)	7 (21.2%)
F508del/F508del	G/G	10 (83.3%)	2 (16.7%)	0.566	0.452
	G/T and T/T	18 (72%)	7 (28%)
F508del	Age	≤ 154 months	> 154 months
-/-	G/G	4 (26.7%)	11 (73.3%)	0.032	0.857
	G/T and T/T	8 (24.2%)	25 (75.8%)
F508del/-	G/G	15 (55.6%)	12 (44.4%)	0.297	0.586
	G/T and T/T	16 (48.5%)	17 (51.5%)
F508del/F508del	G/G	9 (75%)	3 (25%)	1.009	0.315
	G/T and T/T	22 (88%)	3 (12%)

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