Table 4 Association IVS4G > T mutation in TCF7L2 gene after genotypic groupings, distributed by genotype for the mutation in the CFTR gene delF508 with clinical variables in cystic fibrosis patients followed at the Pediatric Clinic at UNICAMP with the distribution by mutations in the CFTR gene
F508del | Sex | Male | Female | Chi-square | p-value |
|---|---|---|---|---|---|
-/- | G/G | 8 (53.3%) | 7 (46.7%) | 0.257 | 0.613 |
G/T and T/T | 15 (45.5%) | 18 (54.5%) | |||
F508del/- | G/G | 13 (48.1%) | 14 (51.9%) | 0.931 | 0.335 |
G/T and T/T | 20 (60.6%) | 13 (39.4%) | |||
F508del/F508del | G/G | 5 (41.7%) | 7 (58.3%) | 0.018 | 0.893 |
G/T and T/T | 11 (44%) | 14 (54%) | |||
F508del | Diabetes | No | Yes | ||
-/- | G/G | 12 (80%) | 3 (20%) | 0.01 | 0.919 |
G/T and T/T | 26 (81.3%) | 6 (18.8%) | |||
F508del/- | G/G | 19 (70.4%) | 8 (29.6%) | 2.652 | 0.103 |
G/T and T/T | 28 (87.5%) | 4 (12.5%) | |||
F508del/F508del | G/G | 8 (66.7%) | 4 (33.3%) | 1.437 | 0.231 |
G/T and T/T | 21 (84%) | 4 (16%) | |||
F508del | Meconium ileus | No | Yes | ||
-/- | G/G | 15 (100%) | - | 1.455 | 0.228 |
G/T and T/T | 30 (90.9%) | 3 (9.1%) | |||
F508del/- | G/G | 22 (81.5%) | 5 (18.5%) | 0.067 | 0.795 |
G/T and T/T | 26 (78.8%) | 7 (21.2%) | |||
F508del/F508del | G/G | 10 (83.3%) | 2 (16.7%) | 0.566 | 0.452 |
G/T and T/T | 18 (72%) | 7 (28%) | |||
F508del | Age | ≤ 154 months | > 154 months | ||
-/- | G/G | 4 (26.7%) | 11 (73.3%) | 0.032 | 0.857 |
G/T and T/T | 8 (24.2%) | 25 (75.8%) | |||
F508del/- | G/G | 15 (55.6%) | 12 (44.4%) | 0.297 | 0.586 |
G/T and T/T | 16 (48.5%) | 17 (51.5%) | |||
F508del/F508del | G/G | 9 (75%) | 3 (25%) | 1.009 | 0.315 |
G/T and T/T | 22 (88%) | 3 (12%) |