ENU-induced phenovariance in mice: inferences from 587 mutations

BMC Research Notes

Table 5 Frequencies of ENU-induced DNA base changes in the sense strand

DNA base change	p^†	Phenotypic mutations		Incidental mutations		Phenotypic + Incidental mutations
		Mutation number	P values*	Mutation number	P values*	Total number	P values*
A→T	0.5470	23	0.00397	39	0.000435	62	0.00000725
T→A	0.4530	39		64		103
A→G	0.5780	20	0.00071	70	0.9425	90	0.00322
T→C	0.4220	36		66		102
A→C	0.5308	2	0.06310	8	0.3982	10	0.09730
T→G	0.4692	7		9		16
G→T	0.5341	10	0.6600	14	0.3876	24	0.4289
C→A	0.4659	8		15		23
G→A	0.5563	9	0.1202	35	0.1401	44	0.0533
C→T	0.4437	13		37		50
G→C	0.5187	0	--	1	1.0	1	1.0
C→G	0.4813	0		0		0
Total		167**		358 ^††		527

^†Relative probability of non-synonymous nucleotide change in the sense strand (see Methods).
*Likelihood of observed or greater departure from the expected ratio by exact binomial calculation.
**Not included were 11 non-critical splice junction mutations, 3 large deletions, 2 single base insertions, 1 single base deletion, and 1 dinucleotide transition.
^††Not included were 44 non-critical splice junction mutations.

ISSN: 1756-0500