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Table 2 Predictors of response to NSAIDs on the univariate level with three different definitions of responder

From: Clinically important improvement in the WOMAC and predictor factors for response to non-specific non-steroidal anti-inflammatory drugs in osteoarthritic patients: a prospective study

Independent variable 16% improvement in the WOMAC Transition Both criteria
  OR IC 95% OR IC 95% OR IC 95%
Total WOMAC score at baseline -   0.43* 0.22-0.82 -  
Age > 57 (years) 1.20 0.66-2.16 0.41 0.21-0.77 1.14 0.61-2.13
BMI > 31 (kg/m2) 1.79* 1.02-3.28 0.81 0.43-1.49 1.18 0.63-2.18
Joint space width > 3.5 mm 0.48* 0.23-0.98 1.59+ 0.76-3.21 0.61+ 0.28-1.30
Knee height > 49 cm 2.46* 1.18-5.13 0.75 0.36-1.51 1.05 0.49-2.25
KL Grade > 2 1.34 0.71-2.54 0.47* 0.23-0.97 1.26 0.68-2.45
Duration of OA > 4 (month) 1.14 0.51-2.56 0.75 0.39-1.72 1.38 0.59-3.21
Previous knee injuries 5.27* 1.83-15.38 2.25+ 0.86-5.85 3.92* 1.59-9.67
Co morbidities 0.71 0.38-1-28 0.67+ 0.35-1.21 0.60+ 0.32-1.13
Existence of back pain 1.77 0.15-19.9 18.2 0.51-24.5 3.39 0.31-38.2
High level of education 2.19* 1.15-4.19 0.63 0.33-1.21 1.72+ 0.91-3.25
Number of pregnancies > 4 2.48* 1.06-5.73 0.51+ 0.21-1.21 1.92+ 0.81-4.51
EQ index at baseline > 0.36 0.5+ 0.24-1 1.47 0.73-3.07 0.58+ 0.27-1.26
VAS EQ 5D at baseline > 40 0.21* 0.09-0.41 1.56+ 0.73-3.32 0.29* 0.12-0.71
  1. +P < 0.25 * P < 0.05
  2. Continuous variables were dichotomized by median as cut-off
  3. Univariate analysis for the association between "Total WOMAC score at baseline" and the response definitions "16% improvement in the WOMAC" and "both criteria," respectively, are not represented because these response definitions adjust for the expected high correlation of WOMAC baseline score and the change of the WOMAC