|
Clustering of lung tissue specific cancer Biomarkers
|
DDD1
|
DDD2
|
|---|
|
Panel / Cluster of Biomarker
|
Type / class of Biomarker
|
GeneSymbol
|
Transcript frequency
|
Foldchange
|
Transcript frequency
|
Foldchange
|
|---|
| | | |
Pool A (normallung tissues)
|
Pool B (Normalbody tissuesexcluding lung)
| |
Pool A (normallung tissues)
|
Pool B (lungtissue specificcancers)
| |
|---|
|
Panel 1 / Cluster 4
|
Lung cancer metastasisdiagnostic markers
|
UCHL1
|
0
|
0.0002
|
-
|
0
|
0.0011
|
+
|
| | |
LTF
|
0.0224
|
0.0018
|
+12.44
|
0.0224
|
0.0002
|
-112
|
|
Panel 2 / Cluster 5
|
Chemotherapy/ drugresistance related lungcancer biomarkers
|
TUBA1B
|
0
|
0.0002
|
-
|
0
|
0.0013
|
+
|
| | |
RPSA
|
0.0001
|
0.0004
|
-4
|
0.0001
|
0.0027
|
+27
|
| | |
RPL9
|
0.0002
|
0.0006
|
-3
|
0.0002
|
0.002
|
+10
|
| | |
TMSB4X
|
0.0004
|
0.001
|
-2.5
|
0.0004
|
0.0016
|
+4
|
| | |
COPB1
|
0.0007
|
0.0002
|
+3.5
|
0.0007
|
0
|
-
|
| | |
API5
|
0.0007
|
0.0003
|
+2.3
|
0.0007
|
0
|
-
|
| | |
NT5C2
|
0.0008
|
0.0003
|
+2.6
|
0.0008
|
0
|
-
|
| | |
CPN
|
0.0009
|
0.0001
|
+9
|
0.0009
|
0
|
-
|
| | |
PRKAR1A
|
0.0017
|
0.0006
|
+2.83
|
0.0017
|
0
|
-
|
|
Panel 3 / Cluster 6
|
Hypoxia related lungcancer biomarkers
|
FTL
|
0.0001
|
0.0011
|
-11
|
0.0001
|
0.0065
|
+65
|
| | |
COL1A2
|
0.0001
|
0.0006
|
-6
|
0.0001
|
0.0023
|
+23
|
| | |
GAPDH
|
0.0001
|
0.001
|
-10
|
0.0001
|
0.0011
|
+11
|
| | |
IGKC
|
0.0002
|
0.0009
|
-4.5
|
0.0002
|
0.0016
|
+8
|
| | |
ALDOA
|
0.0002
|
0.0006
|
-3
|
0.0002
|
0.0014
|
+7
|
| | |
COL1A1
|
0.0001
|
0.0004
|
-4
|
0.0001
|
0.0009
|
+9
|
| | |
FN1
|
0.0025
|
0.0012
|
+2.08
|
0.0025
|
0.0007
|
-3.57
|
| | |
TGM2
|
0.0026
|
0.0008
|
+3.25
|
0.0026
|
0.0007
|
-3.71
|
| | |
FOS
|
0.0015
|
0.0007
|
+2.14
|
0.0015
|
0.0002
|
-7.5
|
| | |
CTNNA1
|
0.0034
|
0.0008
|
+4.25
|
0.0034
|
0.0003
|
-11.33
|
| | |
FOSB
|
0.0024
|
0.0003
|
+8
|
0.0024
|
0.0002
|
-12
|
| | |
APLP2
|
0.0109
|
0.0044
|
+2.47
|
0.0109
|
0.0008
|
-13.63
|
| | |
NCOA4
|
0.0016
|
0.0005
|
+3.2
|
0.0016
|
0.0001
|
-16
|
| | |
HIF1A
|
0.0011
|
0.0004
|
+2.75
|
0.0011
|
0
|
-
|
| | |
AZIN1
|
0.001
|
0.0005
|
+2
|
0.001
|
0
|
-
|
| | |
EHF
|
0.001
|
0.0001
|
+10
|
0.001
|
0
|
-
|
| | |
TICAM2
|
0.001
|
0.0003
|
+3.33
|
0.001
|
0
|
-
|
| | |
NAMPT
|
0.0008
|
0.0002
|
+4
|
0.0008
|
0
|
-
|
| | |
TNFRSF1A
|
0.0008
|
0.0004
|
+2
|
0.0008
|
0
|
-
|
| | |
DMBT1
|
0.0008
|
0.0001
|
+8
|
0.0008
|
0
|
-
|
| | |
CSNK1A1
|
0.0007
|
0.0003
|
+2.33
|
0.0007
|
0
|
-
|
|
Panel 4 / Cluster 7
|
Lung cancer specificextra cellular matrixbiomarkers
|
TFPI2
|
0
|
0.0004
|
-
|
0
|
0.002
|
+
|
| | |
RPL10
|
0.0001
|
0.0007
|
-7
|
0.0001
|
0.0014
|
+14
|
| | |
SFTPA1
|
0.0004
|
0
|
+
|
0.0001
|
0.0011
|
+11
|
| | |
KIAA1324
|
0.0013
|
0.0002
|
+6.5
|
0.0013
|
0
|
-
|
| | |
CRISP3
|
0.0009
|
0.0001
|
+9
|
0.0009
|
0
|
-
|
| | |
NET1
|
0.0007
|
0.0002
|
+3.5
|
0.0007
|
0
|
-
|
- Note: (−) represents down regulation and (+) represents up regulation. Except SFTPA1, remaining all the up regulated genes in normal condition observed to be down regulated in cancerous condition and vice versa.
