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Table 2 Lung cancer signature biomarker clusters

From: Lung Cancer Signature Biomarkers: tissue specific semantic similarity based clustering of Digital Differential Display (DDD) data

Clustering of lung tissue specific cancer Biomarkers DDD1 DDD2
Panel / Cluster of Biomarker Type / class of Biomarker GeneSymbol Transcript frequency Foldchange Transcript frequency Foldchange
    Pool A (normallung tissues) Pool B (Normalbody tissuesexcluding lung)   Pool A (normallung tissues) Pool B (lungtissue specificcancers)  
Panel 1 / Cluster 4 Lung cancer metastasisdiagnostic markers UCHL1 0 0.0002 - 0 0.0011 +
   LTF 0.0224 0.0018 +12.44 0.0224 0.0002 -112
Panel 2 / Cluster 5 Chemotherapy/ drugresistance related lungcancer biomarkers TUBA1B 0 0.0002 - 0 0.0013 +
   RPSA 0.0001 0.0004 -4 0.0001 0.0027 +27
   RPL9 0.0002 0.0006 -3 0.0002 0.002 +10
   TMSB4X 0.0004 0.001 -2.5 0.0004 0.0016 +4
   COPB1 0.0007 0.0002 +3.5 0.0007 0 -
   API5 0.0007 0.0003 +2.3 0.0007 0 -
   NT5C2 0.0008 0.0003 +2.6 0.0008 0 -
   CPN 0.0009 0.0001 +9 0.0009 0 -
   PRKAR1A 0.0017 0.0006 +2.83 0.0017 0 -
Panel 3 / Cluster 6 Hypoxia related lungcancer biomarkers FTL 0.0001 0.0011 -11 0.0001 0.0065 +65
   COL1A2 0.0001 0.0006 -6 0.0001 0.0023 +23
   GAPDH 0.0001 0.001 -10 0.0001 0.0011 +11
   IGKC 0.0002 0.0009 -4.5 0.0002 0.0016 +8
   ALDOA 0.0002 0.0006 -3 0.0002 0.0014 +7
   COL1A1 0.0001 0.0004 -4 0.0001 0.0009 +9
   FN1 0.0025 0.0012 +2.08 0.0025 0.0007 -3.57
   TGM2 0.0026 0.0008 +3.25 0.0026 0.0007 -3.71
   FOS 0.0015 0.0007 +2.14 0.0015 0.0002 -7.5
   CTNNA1 0.0034 0.0008 +4.25 0.0034 0.0003 -11.33
   FOSB 0.0024 0.0003 +8 0.0024 0.0002 -12
   APLP2 0.0109 0.0044 +2.47 0.0109 0.0008 -13.63
   NCOA4 0.0016 0.0005 +3.2 0.0016 0.0001 -16
   HIF1A 0.0011 0.0004 +2.75 0.0011 0 -
   AZIN1 0.001 0.0005 +2 0.001 0 -
   EHF 0.001 0.0001 +10 0.001 0 -
   TICAM2 0.001 0.0003 +3.33 0.001 0 -
   NAMPT 0.0008 0.0002 +4 0.0008 0 -
   TNFRSF1A 0.0008 0.0004 +2 0.0008 0 -
   DMBT1 0.0008 0.0001 +8 0.0008 0 -
   CSNK1A1 0.0007 0.0003 +2.33 0.0007 0 -
Panel 4 / Cluster 7 Lung cancer specificextra cellular matrixbiomarkers TFPI2 0 0.0004 - 0 0.002 +
   RPL10 0.0001 0.0007 -7 0.0001 0.0014 +14
   SFTPA1 0.0004 0 + 0.0001 0.0011 +11
   KIAA1324 0.0013 0.0002 +6.5 0.0013 0 -
   CRISP3 0.0009 0.0001 +9 0.0009 0 -
   NET1 0.0007 0.0002 +3.5 0.0007 0 -
  1. Note: (−) represents down regulation and (+) represents up regulation. Except SFTPA1, remaining all the up regulated genes in normal condition observed to be down regulated in cancerous condition and vice versa.