Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis

Table 2 Haplotype frequencies (f _h ) as derived for DEFB104 MSV rs17843871, rs2680507, rs17843872 and rs4259430 by pooled PCR/cloning and Sanger sequencing

Haplotype	Frequency as determined by pooled PCR/sequencing										Group comparison
	PDAC		CARLA1		CP		CARLA2		Human genomic pool		PDAC vs CARLA1	CP vs CARLA2
	No. clones	f_h	No. clones	f_h	No. clones	f_h	No. clones	f_h	No. clones	f_h	P*	P*
GAGC	224	0.40	286	0.34	310	0.41	391	0.34	413	0.38	0.160	0.061
GGGC	152	0.27	207	0.25	200	0.27	277	0.24	233	0.21	0.540	0.444
GAAT	39	0.07	92	0.11	92	0.12	153	0.13	106	0.10	0.109	0.747
CAGT	60	0.11	65	0.08	63	0.08	91	0.08	62	0.06	0.232	0.813
CAAT	29	0.05	48	0.06	27	0.04	76	0.07	47	0.04	0.773	0.123
CAGC	15	0.03	36	0.04	23	0.03	56	0.05	59	0.05	0.316	0.298
GAGT	22	0.04	28	0.03	9	0.01	41	0.04	54	0.05	0.721	0.079
GAAC	5	0.01	22	0.03	7	0.01	28	0.02	12	0.01	0.136	0.194
GGAT	3	0.01	22	0.03	2	<0.01	14	0.01	27	0.02	0.059	0.217
GGGT	7	0.01	10	0.01	2	<0.01	9	0.01	25	0.02	0.961	0.430
CGGC	6	0.01	5	0.01	2	<0.01	12	0.01	22	0.02	0.547	0.297
CGGT	0	0.00	5	0.01	1	<0.01	3	<0.01	0	0.00	0.163	0.720
GGAC	0	0.00	4	<0.01	0	0.00	0	0.00	6	0.01	0.222	n.a.
CAAC	1	<0.01	2	<0.01	0	0.00	2	<0.01	0	0.00	0.781	0.318
CGAT	1	<0.01	2	<0.01	0	0.00	0	0.00	4	<0.01	0.783	n.a
Total	564		834		738		1.153		1.070		0.239	0.129

* P values for the comparison of case and control haplotype frequencies were based upon simulations as previously described [33].

ISSN: 1756-0500