From expression pattern to genetic association in asthma and asthma-related phenotypes

BMC Research Notes

Table 1 Differently expressed genes in two microarrays studies using bronchial tissues of asthmatic and control subjects

Functional category	Genes
Immune signaling molecules	CX3CR1* ^† , IL7R ^† , CD14* ^† , SFRP1 ^† , SCYA21, SDF1, TNFRSF7, TRA@, CD19, ALOX15* ^† , NOS2A ^† , SCYA5, IL2RB ^† , IL1R2* ^†
Extracellular proteins	COL11A1, FMOD, MUC5AC ^£ , MUC2 ^£ , COL2A1, AGC1, FBLN1, GPC3, MUC4 ^£ , SFRP4
Immune response	IGKC, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB4, TRBA* ^£ , MS4A1, IGHM, IGLJ3, CEACAM5, ERAP2, IGHG1, IGJ, IGLA, IGKV1D-13*
Intracellular signaling	PTPRC,IFI6, ARHGEF16, PSPHL, GNB2, SYK ^£ , PPP1R3C, PHLDA1, TYROBP, FKBP8, PIM2, FLRT3
Proteolytic enzymes	CPA3, GZMA, CTSC, CTSG* ^£ , PSMA6, TPSB1 ^£ , SERPINB2, SERPINB4, SPINK5*
Transmembrane proteins	TM4SF3, KLRC3, LGALS7, NKG7, ARHGAP4, ADRA2A, CLCA2, CLDN10, KCNJ16
Free radical metabolism	GPX3, GSTA2, CYBA, CYBB, NQO1 ^†
Gene transcription	TCF21, ZNF38, LDB1, MAF, STAT5A
Cell growth and proliferation	GAS1, IGFBP6, CORO1A, TRIM16, EMP3, OGN, S100A14, S100P, SFN
Cell adhesion molecules	ITGB2, POSTN*
Complement components	C1QB, C7 ^£ , CFD
Metabolic enzymes	RBP4, ALDH3A1, FA2H, ADH1B, PIK3R1
Structural proteins	KRT23, TNC ^£

* Genes associated with asthma, atopy or atopic asthma.
^† Association between these genes and asthma or asthma-related phenotype (atopy or allergic asthma) was already investigated in other articles using the SLSJ familial asthma study[10–12, 45].
^£ Protein related to asthma.

ISSN: 1756-0500