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Table 1 Differently expressed genes in two microarrays studies using bronchial tissues of asthmatic and control subjects

From: From expression pattern to genetic association in asthma and asthma-related phenotypes

Functional category Genes
Immune signaling molecules CX3CR1* , IL7R , CD14* , SFRP1 , SCYA21, SDF1, TNFRSF7, TRA@, CD19, ALOX15* , NOS2A , SCYA5, IL2RB , IL1R2*
Extracellular proteins COL11A1, FMOD, MUC5AC £ , MUC2 £ , COL2A1, AGC1, FBLN1, GPC3, MUC4 £ , SFRP4
Immune response IGKC, HLA-DPB1*, HLA-DQA1*, HLA-DQB1*, HLA-DRB4, TRBA £ , MS4A1, IGHM, IGLJ3, CEACAM5, ERAP2, IGHG1*, IGJ, IGLA, IGKV1D-13
Intracellular signaling PTPRC,IFI6, ARHGEF16, PSPHL, GNB2, SYK £ , PPP1R3C, PHLDA1, TYROBP, FKBP8, PIM2, FLRT3
Proteolytic enzymes CPA3*, GZMA, CTSC, CTSG £ , PSMA6, TPSB1 £ , SERPINB2, SERPINB4*, SPINK5
Transmembrane proteins TM4SF3, KLRC3, LGALS7, NKG7, ARHGAP4, ADRA2A, CLCA2, CLDN10, KCNJ16
Free radical metabolism GPX3, GSTA2, CYBA*, CYBB, NQO1*
Gene transcription TCF21, ZNF38, LDB1, MAF, STAT5A
Cell growth and proliferation GAS1, IGFBP6, CORO1A, TRIM16, EMP3, OGN, S100A14, S100P, SFN
Cell adhesion molecules ITGB2, POSTN*
Complement components C1QB, C7 £ , CFD
Metabolic enzymes RBP4, ALDH3A1, FA2H, ADH1B, PIK3R1
Structural proteins KRT23, TNC £
  1. * Genes associated with asthma, atopy or atopic asthma.
  2. Association between these genes and asthma or asthma-related phenotype (atopy or allergic asthma) was already investigated in other articles using the SLSJ familial asthma study[1012, 45].
  3. £ Protein related to asthma.