An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an “equivalent” bovine landscape

Table 4 Location of the genes encoding muscle structural protein subunits in the AC landscape

Module name	Slow twitch fibres¹	Fast twitch fibres	Both slow and fast twitch fibres	Fibre type specificity is not known
Muscle	MYL2	TNNT3		TNNT1, FHL1, TMOD4, MYOZ1
Near “muscle”	TTN1	MYH2	ACTN2	TRIM54, TCAP, MYOT, DES, MYBPC1
Near “mitochondrial”		TNNC2, MYLPF, MYL1		SMPX
Near “regulation of ubiquitin–protein ligase activity”			ACTA1 ²
Near “translation”		TPM1
Elsewhere in AClandscape			OBSCN, NEB,	DMD, ANKRD1
Not in the AClandscape	MYL3, MYH7, TNNC1, TNNI1, TPM3	MYH1, MYBPC2, TNNI2,	MYBPH, ACTN3	MYOM2, MYOM3, MYBPC3, TNNI3, TNNT2, TPM2, MYPN, KBTBD10, KBTBD5, CSRP3, LMOD2, UNC45B, SGCA, CMYA5, PDLIM3, LRRC39, XIRP2, TRIM63

¹Fibre type assignments of proteins are from [13], except for TMOD1 and TMOD4 [14] and MYL6B [15].
²Expression of genes encoding proteins in bold are negatively correlated with the majority of the members of the module.

ISSN: 1756-0500