Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle – an update

Konold, Timm; Arnold, Mark E; Austin, Anthony R; Cawthraw, Saira; Hawkins, Steve AC; Stack, Michael J; Simmons, Marion M; Sayers, A Robin; Dawson, Michael; Wilesmith, John W; Wells, Gerald AH

doi:10.1186/1756-0500-5-674

Table 2 Times from exposure to onset of stages and cull with experimental outcome in BSE-negative cattle

From: Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle – an update

Animal identity	Possible signs	Probable signs	Definite signs	Cull	Experimental outcome
1 g dose group
CN939	49	––	––	53	Spastic syndrome
CM933	56	––	––	144*
100 mg dose group
CN950	––	––	––	97	Urethral obstruction
CM921	––	––	––	100	Hip injury
CN946	117	––	––	144	Died, no cause identified
CM906	––	––	––	145*
CM914	––	––	––	145*
CN948	––	––	––	145*
CN949	––	––	––	145*
10 mg dose group
CN952	––	––	––	84	Indigestion?
CM915	––	––	––	85	Metabolic disease
CM929	71	––	––	101	Muscle trauma
CM919	––	––	––	119	Osteoarthrosis
CM931	––	––	––	123	Osteoarthrosis
CN941	65	––	––	126	Recumbency, hypophosphataemia
CM904	53	––	––	136	Recumbency, thyroid adenoma
CM899	––	––	––	144*
CM916	47	––	––	144*
CM924	138	––	––	144*	Compressive spinal cord lesion
CM913	––	––	––	145*
CM928	––	––	––	145*
CN943	––	––	––	145*
1 mg dose group
CM922	64	––	––	81	Renal failure
CM932	––	––	––	103	Died, no cause identified
CM926	––	––	––	104	Urethral obstruction
CN955	––	––	––	109	Died – indigestion?
CM910	73	––	––	112	Osteoarthrosis
CM907	––	––	––	123	Spastic syndrome
CM920	94	––	––	125	Osteoarthrosis
CM930	––	––	––	136	Recumbency, meningeal tumour
CM905	62	––	––	144*
CN940	––	––	––	144*
CM896	––	––	––	145*
CM903	62	––	––	145*
CN937	106	––	––	145*	Hippocampal lesion (focal dysplasia)
CN945	127	––	––	145*
Undosed controls
CM908	––	––	––	39	Vertebral fracture
CM918	62	––	––	97	Pleural mesothelioma
CM925	––	––	––	59	Femoral fracture
CM856	61	––	––	101	Septic arthritis
CM858	71	––	––	103	Muscle injury, spastic syndrome
CM901	56	––	––	125	Chronic enteritis (Johne’s disease)
CM927	135	––	––	144	Found dead (indigestion?)
CM935	32	––	––	145*
CM859	117	––	––	145*
CM902	––	––	––	145*

All cattle belonged to the second phase of the study.
^* Culled because of termination of study.
Times are displayed in months. For controls, months are displayed as months after test group exposure.

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ISSN: 1756-0500

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