Figure 3

GSEA + MIMGO and validation of the identified “microarray data with upregulation”. A, Matrix for pair-wise comparison between microarray data. This matrix is prepared for GO term “A”. Identifiers (I–VIII) in the first row and column show the microarray data. The asterisk describes the relative fold inductions of each gene in microarray data I to II. The cells marked with 1 indicate that GO term “A” annotates significantly more upregulated genes in its row identifier than in its column identifier. B, The average expression of genes annotated with GO term “A” in each microarray result. Each number (I–VIII) on the horizontal axis represents a microarray result. The solid line represents the average expression of genes annotated with GO term “A” in each microarray result. The dotted line describes the sum of the average and the standard deviation for the average expression (i.e., diamond marks on the solid line) of genes annotated with GO term “A” in all the microarray data (I–VIII). C, Validation of “microarray data with upregulation” identified by GSEA + MIMGO. Each number (I–VIII) represents a microarray result. When a statistically significant number of cells marked with 1 is in a row of a matrix as in Figure 3A, the corresponding cell of “GSEA + MIMGO” in Figure 3C is marked with 1. Microarray data that show a value above the dotted line in Figure 3B are marked with 1 in “> (avg + std)” of Figure 3C.